Evidence map›Paper›PMID 35401568›Full record

ReviewFrontiers in immunology2022

MicroRNA-Mediated Epigenetic Regulation of Rheumatoid Arthritis Susceptibility and Pathogenesis.

Cen Chang, Lingxia Xu, Runrun Zhang, Yehua Jin, Ping Jiang, Kai Wei, Linshuai Xu, Yiming Shi, Jianan Zhao, Momiao Xiong and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  10. Rheumatoid Arthritis: Biomarkers and the Latest Breakthroughs.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Cen ChangGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Lingxia XuGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Runrun ZhangThe Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Yehua JinGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ping JiangGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Kai WeiGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Linshuai XuGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yiming ShiGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jianan ZhaoGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Momiao XiongDepartment of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston, TX, United States.
Shicheng GuoCenter for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, United States.
Dongyi HeGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai University of Traditional Chinese Medicine · CNShanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine · CNAffiliated Hospital of Shandong University of Traditional Chinese Medicine · CNThe University of Texas Health Science Center at Houston · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) play crucial roles in regulating the transcriptome and development of rheumatoid arthritis (RA). Currently, a comprehensive map illustrating how miRNAs regulate transcripts, pathways, immune system differentiation, and their interactions with terminal cells such as fibroblast-like synoviocytes (FLS), immune-cells, osteoblasts, and osteoclasts are still laking. In this review, we summarize the roles of miRNAs in the susceptibility, pathogenesis, diagnosis, therapeutic intervention, and prognosis of RA. Numerous miRNAs are abnormally expressed in cells involved in RA and regulate target genes and pathways, including NF-κB, Fas-FasL, JAK-STAT, and mTOR pathways. We outline how functional genetic variants of

Indexed as

Arthritis, RheumatoidMicroRNAsSynoviocytesBiomarkersEpigenesis, GeneticHumansBiomarkersMicroRNAsepigeneticsmicroRNApathogenesisrheumatoid arthritissusceptibility

Identifiers

PMID35401568
PMCPMC8987113
OpenAlexW4220685209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.