Evidence map›Paper›PMID 35402865›Full record

ArticleiScience2022

Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress.

Carly M Darden, Srividya Vasu, Jordan Mattke, Yang Liu, Christopher J Rhodes, Bashoo Naziruddin, Michael C Lawrence

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Carly M DardenIslet Cell Laboratory, Baylor Scott & White Research Institute, Dallas, TX 75204, USA.
Srividya VasuIslet Cell Laboratory, Baylor Scott & White Research Institute, Dallas, TX 75204, USA.
Jordan MattkeIslet Cell Laboratory, Baylor Scott & White Research Institute, Dallas, TX 75204, USA.
Yang LiuAnnette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA.
Christopher J RhodesKovler Diabetes Center, Department of Medicine, Section of Endocrinology, Diabetes & Metabolism, University of Chicago, Chicago, IL 60637, USA.
Bashoo NaziruddinAnnette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA.
Michael C LawrenceIslet Cell Laboratory, Baylor Scott & White Research Institute, Dallas, TX 75204, USA.
Baylor Scott & White Health · USBaylor University · USBaylor University Medical Center · USUniversity of Chicago · US

Funding

The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6M
Hepatocyte Surface Engineering for Improved Post-transplant ViabilityR15DK127340 · NIDDK · BAYLOR UNIVERSITY · PI KANE, BOB R · 2020 to 2020
$431k
NIDDK NIH HHS R15 DK127340NIDDK NIH HHS UC4 DK098085
6 · The paper itself

Abstract

Pancreatic islets respond to metabolic and inflammatory stress by producing hormones and other factors that induce adaptive cellular and systemic responses. Here we show that intracellular Ca

Indexed as

Cell biologyDiabetologyEndocrinologyMolecular biologyMolecular interaction

Identifiers

PMID35402865
PMCPMC8983383
OpenAlexW4220769003

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.