Evidence map›Paper›PMID 35402869›Full record

ArticleiScience2022

Functional and structural modifications of influenza antibodies during pregnancy.

Madeleine F Jennewein, Martina Kosikova, Francesca J Noelette, Peter Radvak, Carolyn M Boudreau, James D Campbell, Wilbur H Chen, Hang Xie, Galit Alter, Marcela F Pasetti

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05856396 (Maternal Determinants of Infant Immunity to Pertussis), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05856396 phase4completednot on this mapstarted 2023, after this paper: background citation

Maternal Determinants of Infant Immunity to Pertussis

TypeinterventionalSponsorCentre Hospitalier Universitaire Saint PierreRan2023 to 2025Enrolled200ConditionsVaccination, Infection, Maternal-Fetal Relations, PertussisArmsTriaxis® (Pertussis-containing vaccine), Vaxelis® (Pertussis-containing vaccine)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Endothelial cells sialylate IgG within the FcRn-mediated recycling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Immunomodulation of Antibody Glycosylation through the Placental Transfer.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Madeleine F JenneweinThe Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Martina KosikovaLaboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.
Francesca J NoeletteThe Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Peter RadvakLaboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.
Carolyn M BoudreauThe Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
James D CampbellCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Wilbur H ChenCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Hang XieLaboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.
Galit AlterThe Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Marcela F PasettiCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Ragon Institute of MGH, MIT and Harvard · USCenter for Biologics Evaluation and Research · USUniversity of Maryland, Baltimore · US

Funding

Transferred ImmunityU19AI145825 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI MARCHANT, ARNAUD · 2021 to 2025
$16.0M
NIAID NIH HHS U19 AI145825
6 · The paper itself

Abstract

Pregnancy represents a unique tolerogenic immune state which may alter susceptibility to infection and vaccine response. Here, we characterized humoral immunity to seasonal influenza vaccine strains in pregnant and non-pregnant women. Although serological responses to influenza remained largely intact during late pregnancy, distinct modifications were observed. Pregnant women had reduced hemagglutinin subtype-1 (H1)- IgG, IgG1, IgG2, and IgG3, hemagglutination inhibition, and group 1 and 2 stem IgG titers. Intriguingly, H1-specific avidity and FcγR1 binding increased, and influenza antibodies had distinct Fc and Fab glycans characterized by increased di-galactosylation and di-sialylation. H1-specific Fc-functionality (i.e. monocyte phagocytosis and complement deposition) was moderately reduced in pregnancy. Multivariate antibody analysis revealed two distinct populations (pregnant vs. non-pregnant) segregated by H1 FcγR1 binding, H1-IgG levels, and Fab and Fc glycosylation. Our results demonstrated a structural and functional modulation of influenza humoral immunity during pregnancy that was antigen-specific and consistent with reduced inflammation and efficient placental transport.

Indexed as

PregnancyVirology

Identifiers

PMID35402869
PMCPMC8991102
OpenAlexW4220814965

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.