Evidence map›Paper›PMID 35404085›Full record

ArticleJournal of virology2022

Neuronal miR-138 Represses HSV-2 Lytic Infection by Regulating Viral and Host Genes with Mechanistic Differences from HSV-1.

Siyu Chen, Yue Deng, Hongjia Chen, Yuqi Lin, Xuewei Yang, Boqiang Sun, Dongli Pan

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

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  9. The Role of miR-138 in Cardiovascular Diseases.BioMed research international · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Siyu ChenState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, Zhejiang, China.
Yue DengState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, Zhejiang, China.
Hongjia ChenState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, Zhejiang, China.
Yuqi LinState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, Zhejiang, China.
Xuewei YangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, Zhejiang, China.
Boqiang SunState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, Zhejiang, China.
Dongli PanState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, Zhejiang, China.ORCID 0000-0002-0421-6242
First Affiliated Hospital Zhejiang University · CN

Funding

VIral and host mechanisms that tilt the HSV lytic/latent balanceP01AI098681 · NIAID · HARVARD MEDICAL SCHOOL · PI PESOLA, JEAN M · 2013 to 2023
$19.2M
NIAID NIH HHS P01 AI098681
6 · The paper itself

Abstract

Herpes simplex virus 2 (HSV-2) establishes latent infection in dorsal root ganglion (DRG) neurons after productive (lytic) infection in peripheral tissues. A neuron-specific microRNA, miR-138, favors HSV-1 latency by repressing viral

Indexed as

Herpes SimplexHerpesvirus 2, HumanMicroRNAsNeuronsAnimalsForkhead Transcription FactorsGene Expression Regulation, ViralHerpesvirus 1, HumanImmediate-Early ProteinsMiceOctamer Transcription Factor-1Ubiquitin-Protein LigasesVirus LatencyVirus ReplicationForkhead Transcription FactorsFoxc1 protein, mouseImmediate-Early ProteinsMicroRNAsMIRN138 microRNA, mouseOctamer Transcription Factor-1Pou2f1 protein, mouseUbiquitin-Protein LigasesVmw110 protein, Human herpesvirus 1FOXC1HSV-2ICP0latencymiR-138neuronsOCT-1

Identifiers

PMID35404085
PMCPMC9093125
OpenAlexW4223507477

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.