Evidence map›Paper›PMID 35405248›Full record

Trial reportExperimental gerontology2022

Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H

Alec I McKenzie, Ziad S Mahmassani, Jonathan J Petrocelli, Naomi M M P de Hart, Dennis K Fix, Patrick J Ferrara, Paul C LaStayo, Robin L Marcus, Matthew T Rondina, Scott A Summers and 4 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental gerontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT03107884. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03107884 early_phase1active not recruiting

Metformin to Prevent Inactivity-induced Loss of Muscle Health During Aging

Ran2019Enrolled64Registered outcomes2Posted comparisons0ConditionsInsulin Resistance, Muscle AtrophyArmsMetformin (2 week run-in only), Metformin (Bed Rest), Placebo (2 week run-in only), Placebo (Bed Rest)
Open the trial in the graph
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Sarcopenic obesity: emerging mechanisms and therapeutic potential.Metabolism: clinical and experimental · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Alec I McKenzieDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA; George E. Wahlen Department of Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center, 500 Foothill Dr., Salt Lake City, UT 84148, USA.
Ziad S MahmassaniDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
Jonathan J PetrocelliDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
Naomi M M P de HartDepartment of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA.
Dennis K FixDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
Patrick J FerraraDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
Paul C LaStayoDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
Robin L MarcusDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
Matthew T RondinaDepartment of Internal Medicine & Molecular Medicine Program, University of Utah School of Medicine, Salt Lake City, UT, USA; George E. Wahlen Department of Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center, 500 Foothill Dr., Salt Lake City, UT 84148, USA; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Scott A SummersDepartment of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA.
Jordan M JohnsonDepartment of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA.
Joel D TrinityDepartment of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA; Department of Internal Medicine & Molecular Medicine Program, University of Utah School of Medicine, Salt Lake City, UT, USA; George E. Wahlen Department of Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center, 500 Foothill Dr., Salt Lake City, UT 84148, USA.
Katsuhiko FunaiDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA; Department of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA.
Micah J DrummondDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA; Department of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA. Electronic address: micah.drummond@hsc.utah.edu.
University of Utah · USGeriatric Research Education and Clinical Center · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · 2022 to 2025
$5.6M
LOOH-induced muscle atrophy with ageR01AG074535 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2023 to 2025
$1.6M
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during DisuseR01HL142603 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Joel Douglas Trinity · 2023 to 2023
$1.0M
The Role of Ceramides in the Pancreatic Beta CellR01DK130296 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$550k
The Role of Ceramides in the Intestinal Stem CellR01DK131609 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$512k
Lands cycle and skeletal muscle insulin actionR01DK127979 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$491k
Mitochondrial membrane lipids and respiratory efficiencyR01DK107397 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$489k
NCATS NIH HHS UL1 TR002538NHLBI NIH HHS R01 HL142603NIA NIH HHS F31 AG059438NIA NIH HHS F99 AG073493NIA NIH HHS R01 AG050781NIA NIH HHS R01 AG074535NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK107397NIDDK NIH HHS R01 DK115824NIDDK NIH HHS R01 DK122001NIDDK NIH HHS R01 DK127979NIDDK NIH HHS R01 DK130296NIDDK NIH HHS R01 DK131609NIDDK NIH HHS R44 DK116450NIGMS NIH HHS R01 GM144613NIH HHS S10 OD016232NIH HHS S10 OD018210NIH HHS S10 OD021505
6 · The paper itself

Abstract

BACKGROUND AND

aimsMetformin is the most commonly prescribed medication to treat diabetes. Emerging evidence suggests that metformin could have off target effects that might help promote healthy muscle aging, but these effects have not been thoroughly studied in glucose tolerant older individuals. The purpose of this study was to investigate the short-term effects of metformin consumption on skeletal muscle mitochondrial bioenergetics in healthy older adults.

methodsWe obtained muscle biopsy samples from 16 healthy older adults previously naïve to metformin and treated with metformin (METF; 3F, 5M), or placebo (CON; 3F, 5M), for two weeks using a randomized and blinded study design. Samples were analyzed using high-resolution respirometry, immunofluorescence, and immunoblotting to assess muscle mitochondrial bioenergetics, satellite cell (SC) content, and associated protein markers.

resultsWe found that metformin treatment did not alter maximal mitochondrial respiration rates in muscle compared to CON. In contrast, mitochondrial H

conclusionsThese findings suggest that acute exposure to metformin does not impact mitochondrial respiration in aged, glucose-tolerant muscle, but rather, influences mitochondrial-free radical and SC dynamics. CLINICAL

trial registrationNCT03107884, clinicaltrials.gov.

Indexed as

MetforminAgedGlucoseHumansHydrogen PeroxideMitochondriaMitochondria, MuscleMuscle, SkeletalGlucoseHydrogen PeroxideMetforminAgingComplex I respirationFree radicalsInsulin sensitizersMetabolismMitochondriaMuscle stem cells

Identifiers

PMID35405248
PMCPMC9237837
OpenAlexW4223506797

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.