ArticleAnimals : an open access journal from MDPI2022
Immunoexpression of Relaxin and Its Receptors in Stifle Joints of Dogs with Cranial Cruciate Ligament Disease.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Integrating Mechanical Loading, Mechanotransduction, and Biological Responses in Musculoskeletal Tissues Across the Lifespan: Regulation Influenced by Cells, Extracellular Matrix, and Sex.Results and problems in cell differentiation · 2026Review
- Elasticity mapping of gastrocnemius fascia and myotendinous junction of the medial gastrocnemius during passive ankle and knee dorsiflexion.Frontiers in sports and active living · 2026Article
- Optimal placement of the temporary fixation pin in tibial plateau leveling osteotomy: a canine ex vivo study.BMC veterinary research · 2025Article
- Thermographic Evaluation of the Stifle Region in Dogs with a Rupture of the Cranial Cruciate Ligament.Animals : an open access journal from MDPI · 2025Article
- Canine Cranial Cruciate Ligament Disease (CCLD): A Concise Review of the Recent Literature.Animals : an open access journal from MDPI · 2025Review
- Regulation of Joint Tissues and Joint Function: Is There Potential for Lessons to Be Learned Regarding Regulatory Control from Joint Hypermobility Syndromes?International journal of molecular sciences · 2025Review
- Comparison of Two Preoperative Radiographic Methods for Assessing Tibial Tuberosity Advancement to Achieve a Postoperative Patella Tendon Angle of 90° in Dogs.Animals : an open access journal from MDPI · 2023Article
- Etiopathogenesis of Canine Cruciate Ligament Disease: A Scoping Review.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of spontaneous cranial cruciate ligament rupture in dogs is unknown despite being one of the most impacting orthopedic diseases in dogs. Numerous studies have contributed to the understanding of a multifactorial pathogenesis, this, however, without identifying a pivotal link to explain progressive collagen degeneration and osteoarthritic changes. In human medicine, recent reports have identified relaxin as a triggering factor in ligament ruptures in knee and metacarpal joints. We thus hypothesized that relaxin might also play a role in canine cruciate ligament rupture. Relaxin's primarily known property is connective tissue remodeling through collagenolysis. We therefore investigated relaxin and its cognate receptors LGR7/LGR8 in 18 dogs with cranial cruciate ligament disease (CCLD) and compared them to a group of dogs with normal stifle joints. Applying immunohistochemistry (IHC), double immunofluorescence (dIF), and western blot analysis (WB), we found strong and significantly increased expression of both relaxin and its receptors in ruptured cruciate ligaments, and in synovial membranes. Pattern of immuno-staining on dIF strongly suggests relaxin binding to primed receptors and activation of signaling properties, which in turn may have affected collagen matrix metabolism. Thus, in canine cranial cruciate ligament disease, relaxin/receptor signaling may be a primary trigger for collagen fiber degradation and collagen lysis, eventually followed by ligament rupture.
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Registered trials
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