Evidence map›Paper›PMID 35406118›Full record

ArticleNutrients2022

The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.

Ethar A Mudhish, Abu Bakar Siddique, Hassan Y Ebrahim, Khaldoun S Abdelwahed, Judy Ann King, Khalid A El Sayed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
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  6. Article
  7. Phytochemicals derived fromFrontiers in pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ethar A MudhishSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.ORCID 0000-0003-3677-6575
Abu Bakar SiddiqueSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.
Hassan Y EbrahimSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.ORCID 0000-0001-9057-4582
Khaldoun S AbdelwahedSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.
Judy Ann KingDepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.
Khalid A El SayedSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.ORCID 0000-0002-1456-4064
University of Louisiana at Monroe · USLouisiana State University Health Sciences Center Shreveport · US

Funding

Targeting PCSK9 axis for castration-resistant prostate cancer recurrence suppressionR21CA263290 · NCI · UNIVERSITY OF LOUISIANA AT MONROE · PI EL SAYED, KHALID A · 2022 to 2023
$344k
6 · The paper itself

Abstract

Prostate cancer (PC) is the second leading cause of death in men in the US. PC has a high recurrence rate, and limited therapeutic options are available to prevent disease recurrence. The tryptophan-degrading enzymes 2,3-indoleamine dioxygenase (IDO1) and tryptophan dioxygenase (TDO2) are upregulated in invasive PC. (1

Indexed as

Indoleamine-Pyrrole 2,3,-DioxygenaseProstatic NeoplasmsTryptophan OxygenaseAndrogensAnimalsHumansKynurenineMaleMiceMice, NudeNeoplasm Recurrence, LocalNicotianaProspective StudiesAndrogensIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineTryptophan Oxygenase(4R)-cembratriene-4,6-diolIDO1 and TDO2nude miceprostate cancertobacco cembranoidstobacco leavestumor recurrence

Identifiers

PMID35406118
PMCPMC9003379
OpenAlexW4223486013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.