Evidence map›Paper›PMID 35407472›Full record

ReviewJournal of clinical medicine2022

The Assessment of Endovascular Therapies in Ischemic Stroke: Management, Problems and Future Approaches.

Tadeusz J Popiela, Wirginia Krzyściak, Fabio Pilato, Anna Ligęzka, Beata Bystrowska, Karolina Bukowska-Strakova, Paweł Brzegowy, Karthik Muthusamy, Tamas Kozicz

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Tadeusz J PopielaDepartment of Radiology, Medical College, Jagiellonian University, 31-501 Kraków, Poland.ORCID 0000-0002-6697-2449
Wirginia KrzyściakDepartment of Medical Diagnostics, Medical College, Jagiellonian University, 31-688 Kraków, Poland.ORCID 0000-0003-0452-295X
Fabio PilatoNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.ORCID 0000-0002-7248-3916
Anna LigęzkaDepartment of Medical Diagnostics, Medical College, Jagiellonian University, 31-688 Kraków, Poland.ORCID 0000-0001-5183-3086
Beata BystrowskaDepartment of Toxicology, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0001-6501-8656
Karolina Bukowska-StrakovaDepartment of Clinical Immunology and Transplantology, Institute of Pediatrics, Medical College, Jagiellonian University, 30-663 Kraków, Poland.ORCID 0000-0001-9181-439X
Paweł BrzegowyDepartment of Radiology, Medical College, Jagiellonian University, 31-501 Kraków, Poland.
Karthik MuthusamyDepartment of Clinical Genomics, Mayo Clinic, Rochester, MN 55902, USA.
Tamas KoziczDepartment of Clinical Genomics, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0001-6915-4364
Jagiellonian University · PLMayo Clinic · USMayo Clinic in Florida · USUniversità Campus Bio-Medico · IT

Funding

Jagiellonian University N42/DBS/000199
6 · The paper itself

Abstract

Ischemic stroke accounts for over 80% of all strokes and is one of the leading causes of mortality and permanent disability worldwide. Intravenous administration of recombinant tissue plasminogen activator (rt-PA) is an approved treatment strategy for acute ischemic stroke of large arteries within 4.5 h of onset, and mechanical thrombectomy can be used for large arteries occlusion up to 24 h after onset. Improving diagnostic work up for acute treatment, reducing onset-to-needle time and urgent radiological access angiographic CT images (angioCT) and Magnetic Resonance Imaging (MRI) are real problems for many healthcare systems, which limits the number of patients with good prognosis in real world compared to the results of randomized controlled trials. The applied endovascular procedures demonstrated high efficacy, but some cellular mechanisms, following reperfusion, are still unknown. Changes in the morphology and function of mitochondria associated with reperfusion and ischemia-reperfusion neuronal death are still understudied research fields. Moreover, future research is needed to elucidate the relationship between continuously refined imaging techniques and the variable structure or physical properties of the clot along with vascular permeability and the pleiotropism of ischemic reperfusion lesions in the penumbra, in order to define targeted preventive procedures promoting long-term health benefits.

Indexed as

clotsendovascular therapiesischemic strokemechanical thrombectomymitochondriart-PAthrombolysis

Identifiers

PMID35407472
PMCPMC8999747
OpenAlexW4220658460

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.