ArticleJournal of clinical medicine2022
Detection of Male Hypogonadism in Patients with Post COVID-19 Condition.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone.International journal of molecular sciences · 2026Article
- Scoping review of the emerging definition of long COVID: implications for future research and clinical practice.Revista de salud publica (Bogota, Colombia) · 2025Article
- Clinical Characteristics of Vitamin D Deficiency Detected in Long COVID Patients During the Omicron Phase.Nutrients · 2025Observational
- Review of organ damage from COVID and Long COVID: a disease with a spectrum of pathology.Medical review (2021) · 2025Review
- COVID-19 and Oncofertility: No SARS-CoV-2 in Semen but Inflammation Seems to Affect Sperm Parameters.Journal of medical virology · 2024Article
- Clinical and endocrine features of orthostatic intolerance detected in patients with long COVID.Scientific reports · 2024Article
- Occult endocrine disorders newly diagnosed in patients with post-COVID-19 symptoms.Scientific reports · 2024Article
- Use of testosterone replacement therapy to treat long-COVID-related hypogonadism.Endocrinology, diabetes & metabolism case reports · 2024Article
- Hypocortisolemic ASIA: a vaccine- and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis.Frontiers in immunology · 2024Review
- Post-COVID-19 Demyelinating Disease and Its Effect on the Lower Urinary Tract: A Rare Case of a 14-Year-Old Man.Cureus · 2023Article
- Special Issue "Post-COVID-19 Symptoms in Long-Haulers: Definition, Identification, Mechanisms, and Management".Journal of clinical medicine · 2023Article
- Article
- Utility of Serum Ferritin for Predicting Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Patients with Long COVID.Journal of clinical medicine · 2023Article
- The Complex Interplay between Serum Testosterone and the Clinical Course of Coronavirus Disease 19 Pandemic: A Systematic Review of Clinical and Preclinical Evidence.The world journal of men's health · 2023Review
- Epigenetics of Hypogonadotropic Hypogonadism: Molecular Mimicry between Severe Acute Respiratory Syndrome Coronavirus 2 and KISSR.Global medical genetics · 2023Article
- SARS-CoV-2, fertility and assisted reproduction.Human reproduction update · 2023Review
- Trends in Long COVID Symptoms in Japanese Teenage Patients.Medicina (Kaunas, Lithuania) · 2023Review
- Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan.Journal of clinical medicine · 2022Article
- Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in Japan.Medicina (Kaunas, Lithuania) · 2022Observational
- Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID.Medicina (Kaunas, Lithuania) · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis and prognosis of post COVID-19 condition have remained unclear. We set up an outpatient clinic specializing in long COVID in February 2021 and we have been investigating post COVID-19 condition. Based on the results of our earlier study showing that “general fatigue” mimicking myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is the most common symptom in long COVID patients, a retrospective analysis was performed for 39 male patients in whom serum free testosterone (FT) levels were measured out of 61 male patients who visited our clinic. We analyzed the medical records of the patients’ backgrounds, symptoms and laboratory results. Among the 39 patients, 19 patients (48.7%) met the criteria for late-onset hypogonadism (LOH; FT < 8.5 pg/mL: LOH group) and 14 patients were under 50 years of age. A weak negative correlation was found between age and serum FT level (r = −0.301, p = 0.0624). Symptoms including general fatigue, anxiety, cough and hair loss were more frequent in the LOH group than in the non-LOH group (FT ≥ 8.5 pg/mL). Among various laboratory parameters, blood hemoglobin level was slightly, but significantly, lower in the LOH group. Serum level of FT was positively correlated with the levels of blood hemoglobin and serum total protein and albumin in the total population, whereas these interrelationships were blurred in the LOH group. Collectively, the results indicate that the incidence of LOH is relatively high in male patients, even young male patients, with post COVID-19 and that serum FT measurement is useful for revealing occult LOH status in patients with long COVID.
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