Evidence map›Paper›PMID 35408849›Full record

ReviewInternational journal of molecular sciences2022

Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What's New?

Paola Zanetta, Margherita Ormelli, Angela Amoruso, Marco Pane, Barbara Azzimonti, Diletta Francesca Squarzanti

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Paola ZanettaLaboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0001-8547-3090
Margherita OrmelliLaboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0002-0708-4396
Angela AmorusoProbiotical Research Srl, Via Mattei 3, 28100 Novara, Italy.
Marco PaneProbiotical Research Srl, Via Mattei 3, 28100 Novara, Italy.ORCID 0000-0003-3575-6919
Barbara AzzimontiLaboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0001-6364-6595
Diletta Francesca SquarzantiLaboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0001-8090-7718
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITProbiotical (Italy) · IT

Funding

Cassa di Risparmio di Torino Research Grant for post-DocMinistry of Education, University and Research (MIUR), Italy PhD program in "Food Health and Longevity"University of Piemonte Orientale FAR-2017
6 · The paper itself

Abstract

Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory disorder with multifactorial aetiology and malignant transformation potential. Despite the treatments so far identified, new tailored and safe specific measures are needed. Recently, human microbiota imbalance has been linked to several immune-mediated diseases, opening new therapeutic perspectives for probiotics; besides their ability to directly interact with the host microbiota, they also display a strain-specific immune-modulatory effect. Thus, this non-systematic review aims to elucidate the molecular pathways underlying probiotic activity, mainly those of

Indexed as

Lichen Planus, OralProbioticsAdjuvants, ImmunologicHumansImmunologic FactorsKeratinocytesNF-kappa BAdjuvants, ImmunologicImmunologic FactorsNF-kappa Bapoptosiscytokineshost-probiotic interactionimmune-modulatory activitymicrobial metabolitesmicrobiotaNF-kB signallingoral lichen planus (OLP)probioticsT cells

Identifiers

PMID35408849
PMCPMC8998608
OpenAlexW4221079283

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.