Evidence map›Paper›PMID 35409116›Full record

ArticleInternational journal of molecular sciences2022

Store-Operated Ca

Vladislav Chubinskiy-Nadezhdin, Svetlana Semenova, Valeria Vasileva, Alla Shatrova, Natalia Pugovkina, Yuri Negulyaev

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Orai1 is required for CabioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. CaAmerican journal of physiology. Cell physiology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Optical control of PIEZO1 channels.Nature communications · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vladislav Chubinskiy-NadezhdinInstitute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 Saint-Petersburg, Russia.ORCID 0000-0002-8488-6130
Svetlana SemenovaInstitute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 Saint-Petersburg, Russia.
Valeria VasilevaInstitute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 Saint-Petersburg, Russia.
Alla ShatrovaInstitute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 Saint-Petersburg, Russia.
Natalia PugovkinaInstitute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 Saint-Petersburg, Russia.
Yuri NegulyaevInstitute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 Saint-Petersburg, Russia.
Institute of Cytology · RU

Funding

Russian Science Foundation 18-15-00106
6 · The paper itself

Abstract

Endometrial mesenchymal stem cells (eMSCs) are a specific class of stromal cells which have the capability to migrate, develop and differentiate into different types of cells such as adipocytes, osteocytes or chondrocytes. It is this unique plasticity that makes the eMSCs significant for cellular therapy and regenerative medicine. Stem cells choose their way of development by analyzing the extracellular and intracellular signals generated by a mechanical force from the microenvironment. Mechanosensitive channels are part of the cellular toolkit that feels the mechanical environment and can transduce mechanical stimuli to intracellular signaling pathways. Here, we identify previously recorded, mechanosensitive (MS), stretch-activated channels as Piezo1 proteins in the plasma membrane of eMSCs. Piezo1 activity triggered by the channel agonist Yoda1 elicits influx of Ca

Indexed as

CalciumCalcium SignalingCell MembraneHumansIon ChannelsORAI1 ProteinStem CellsStromal Interaction Molecule 1CalciumIon ChannelsORAI1 ProteinPIEZO1 protein, humanStromal Interaction Molecule 1Ca2+ influxcell migrationendometrial mesenchymal stem cellsmechanosensitive channelsPiezo1 channelsstore-operated Ca2+ channels

Identifiers

PMID35409116
PMCPMC8998223
OpenAlexW4220668661

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.