Evidence map›Paper›PMID 35409226›Full record

ReviewInternational journal of molecular sciences2022

Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation.

Jonathan Mandel, Martina Casari, Maria Stepanyan, Alexey Martyanov, Carsten Deppermann

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
32.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.

  1. Pooled it
  2. Diminished plasma levels of GPIb-Frontiers in medicine · 2026
    Trial
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  17. Plasma Proteomic Profile of Chemotherapy-Induced Severe Neutropenia: A Pilot Discovery Phase Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  20. Review

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jonathan MandelCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.ORCID 0000-0001-9093-1279
Martina CasariCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.ORCID 0000-0001-7137-5588
Maria StepanyanCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.
Alexey MartyanovCenter For Theoretical Problems of Physico-Chemical Pharmacology, 109029 Moscow, Russia.
Carsten DeppermannCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.
Johannes Gutenberg University Mainz · DEMinistry of Health of the Russian Federation · RU

Funding

Deutsche Forschungsgemeinschaft SFB1292 TP08
6 · The paper itself

Abstract

There is accumulating evidence that platelets play roles beyond their traditional functions in thrombosis and hemostasis, e.g., in inflammatory processes, infection and cancer, and that they interact, stimulate and regulate cells of the innate immune system such as neutrophils, monocytes and macrophages. In this review, we will focus on platelet activation in hemostatic and inflammatory processes, as well as platelet interactions with neutrophils and monocytes/macrophages. We take a closer look at the contributions of major platelet receptors GPIb, α

Indexed as

COVID-19ThrombosisBlood PlateletsHemostasisHumansImmunity, InnateInflammationNeutrophilsPlatelet ActivationThromboinflammationatherosclerosiscancerCOVID-19hemostasisinflammationmacrophagesmonocytesNETsneutrophilsplateletsthrombosis

Identifiers

PMID35409226
PMCPMC8998935
OpenAlexW4220815932

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.