Evidence map›Paper›PMID 35409287›Full record

ArticleInternational journal of molecular sciences2022

Structure-Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition.

Jinsoo Kim, Jinyoung Son, Dohee Ahn, Gibeom Nam, Xiaodi Zhao, Hyuna Park, Woojoo Jeong, Sang J Chung

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Frontiers in microbiology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jinsoo KimSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0001-9382-5527
Jinyoung SonDepartment of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Korea.
Dohee AhnSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0001-6661-5129
Gibeom NamSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Xiaodi ZhaoSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Hyuna ParkDepartment of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Korea.
Woojoo JeongDepartment of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Korea.
Sang J ChungSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0002-3501-212X
Sungkyunkwan University · KR

Funding

National Research Foundation of Korea NRF-2012M3A9C4048775National Research Foundation of Korea NRF-2017M3A9C8031995
6 · The paper itself

Abstract

Ginkgolic acid (C13:0) (GA), isolated from Ginkgo biloba, is a potential therapeutic agent for type 2 diabetes. A series of GA analogs were designed and synthesized for the evaluation of their structure-activity relationship with respect to their antidiabetic effects. Unlike GA, the synthetic analog

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceGlucoseHumansInsulinMuscle Fibers, SkeletalPalmitatesSalicylatesSignal TransductionStructure-Activity Relationshipginkgolic acidGlucoseInsulinPalmitatesSalicylatesAktAMPKginkgolic acid analogsglucose uptakeinsulin sensitivityPTPN9 inhibitors

Identifiers

PMID35409287
PMCPMC8999917
OpenAlexW4223487848

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.