Evidence map›Paper›PMID 35409417›Full record

ArticleInternational journal of molecular sciences2022

Direct Reprogramming and Induction of Human Dermal Fibroblasts to Differentiate into iPS-Derived Nucleus Pulposus-like Cells in 3D Culture.

Shoji Seki, Mami Iwasaki, Hiroto Makino, Yasuhito Yahara, Yoshitaka Miyazaki, Katsuhiko Kamei, Hayato Futakawa, Makiko Nogami, Nguyen Tran Canh Tung, Tatsuro Hirokawa and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Concepts of Regeneration for Spinal Diseases in 2022.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Shoji SekiDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-9930-5100
Mami IwasakiDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Hiroto MakinoDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0003-0286-4489
Yasuhito YaharaDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-9304-3728
Yoshitaka MiyazakiKUBIX Inc., ha8-1 Netsuno, Hakusan 920-2161, Japan.
Katsuhiko KameiDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Hayato FutakawaDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Makiko NogamiDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Nguyen Tran Canh TungDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-7757-1878
Tatsuro HirokawaDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-9967-2859
Mamiko TsujiDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Yoshiharu KawaguchiDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
University of Toyama · JPVietnam Military Medical University · VN

Funding

govermental 2DH03801
6 · The paper itself

Abstract

Intervertebral disc (IVD) diseases are common spinal disorders that cause neck or back pain in the presence or absence of an underlying neurological disorder. IVD diseases develop on the basis of degeneration, and there are no established treatments for degeneration. IVD diseases may therefore represent a candidate for the application of regenerative medicine, potentially employing normal human dermal fibroblasts (NHDFs) induced to differentiate into nucleus pulposus (NP) cells. Here, we used a three-dimensional culture system to demonstrate that ectopic expression of

Indexed as

Intervertebral DiscIntervertebral Disc DegenerationNucleus PulposusFibroblastsHumansIntervertebral Disc Displacementalginate beadsdirect reprogramminghuman dermal fibroblastinduced pluripotent stem cellsintervertebral disc diseaseintervertebral disc regenerationnucleus pulposus cell

Identifiers

PMID35409417
PMCPMC8999916
OpenAlexW4223476021

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.