ArticleInternational journal of environmental research and public health2022
Correlations of Salivary and Blood Glucose Levels among Six Saliva Collection Methods.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Extensive comparison of salivary collection, transportation, preparation, and storage methods: a systematic review.BMC oral health · 2024Pooled it
- Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders.Diabetes, obesity & metabolism · 2026Review
- Type 2 diabetes mellitus exacerbates vaginal group BmSphere · 2026Article
- Salivary Glucose Testing for Diabetes Mellitus: A Systematic Review and Meta-Analysis of Current Evidence and Methodological Heterogeneity.Journal of clinical medicine · 2026Review
- Review
- Salivary glucose, salivary interleukin-18, glycemic control, and periodontal status in patients with type 2 diabetes mellitus.Scientific reports · 2025Article
- Clinical study on early warning signal monitoring (salivary indicators) of exercise-induced fatigue in technical winter sports athletes.Pakistan journal of medical sciences · 2025Article
- First report on whole saliva profiling of Landlly pigs for stress, inflammation, immunity, and systemic homeostasis appraisal: a pilot study.Veterinary research communications · 2025Article
- Biosensors based on organic transistors for intraoral biomarker detection.Mikrochimica acta · 2025Review
- Exploring the impact of advanced glycation end products on diabetic salivary gland dysfunctions.Glycoconjugate journal · 2025Review
- Exploring Saliva as a Sample for Non-Invasive Glycemic Monitoring in Diabetes: A Scoping Review.Biomedicines · 2025Review
- Multifilm Mass Transfer and Reaction Rate Kinetics in a Newly Developed In Vitro Digestion System for Carbohydrate Digestion.Foods (Basel, Switzerland) · 2025Article
- The Effect of Vitamin E, Β-Carotene, and Acidophilus Probiotics on The Salivary Gland Flow Rate in Streptozotocin-Induced Diabetes in Rats: An in-vivo Study.Clinical, cosmetic and investigational dentistry · 2025Article
- Additively manufactured microwave sensor for glucose level detection in saliva.Scientific reports · 2024Article
- Recent Advances in Wearable Healthcare Devices: From Material to Application.Bioengineering (Basel, Switzerland) · 2024Review
- The Application of Fluorescence Anisotropy for Viscosity Measurements of Small Volume Biological Analytes.Journal of experimental and theoretical analyses · 2023Article
- Review
- Human Serum and Salivary Metabolomes: Diversity and Closeness.International journal of molecular sciences · 2023Article
- Monitoring saliva compositions for non-invasive detection of diabetes using a colorimetric-based multiple sensor.Scientific reports · 2023Article
- Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSaliva has been studied as a better indicator of disorders and diseases than blood. Specifically, the salivary glucose level is considered to be an indicator of diabetes mellitus (DM). However, saliva collection methods can affect the salivary glucose level, thereby affecting the correlation between salivary glucose and blood glucose. Therefore, this study aims to identify an ideal saliva collection method and to use this method to determine the population and individual correlations between salivary glucose and blood glucose levels in DM patients and healthy controls. Finally, an analysis of the stability of the individual correlations is conducted.
methodsThis study included 40 age-matched DM patients and 40 healthy controls. In the fasting state, saliva was collected using six saliva collection methods, venous blood was collected simultaneously from each study participant, and both samples were analyzed at the same time using glucose oxidase peroxidase. A total of 20 DM patients and 20 healthy controls were arbitrarily selected from the above participants for one week of daily testing. The correlations between salivary glucose and blood glucose before and after breakfast were analyzed. Finally, 10 DM patients and 10 healthy controls were arbitrarily selected for one month of daily testing to analyze the stability of individual correlations.
resultsSalivary glucose levels were higher in DM patients than healthy controls for the six saliva collection methods. Compared with unstimulated saliva, stimulated saliva had decreased glucose level and increased salivary flow. In addition, unstimulated parotid salivary glucose was most correlated with blood glucose level (R
conclusionUnstimulated parotid salivary glucose level is the highest and is most correlated with blood glucose level, which can be accurately used to distinguish DM patients. Meanwhile, the correlation between salivary glucose and blood glucose was found to be relatively high and stable before breakfast. In general, the unstimulated parotid salivary glucose before breakfast presents an ideal saliva collecting method with which to replace blood-glucose use to detect DM, which provides a reference for the prediction of DM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.