Evidence map›Paper›PMID 35411232›Full record

ReviewAmerican journal of cancer research2022

Retinoids as anti-cancer agents and their mechanisms of action.

Ying Jin, Soek Sin Teh, Harrison Lik Nang Lau, Jianbo Xiao, Siau Hui Mah

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Cetyl All-International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ying JinSchool of Biosciences, Faculty of Health and Medical Sciences, Taylor's University (Lakeside Campus) Subang Jaya, Selangor, Malaysia.
Soek Sin TehEnergy and Environment Unit, Engineering and Processing Division, Malaysian Palm Oil Board Kajang, Selangor, Malaysia.
Harrison Lik Nang LauEnergy and Environment Unit, Engineering and Processing Division, Malaysian Palm Oil Board Kajang, Selangor, Malaysia.
Jianbo XiaoNutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo, Ourense Campus Ourense, Spain.
Siau Hui MahSchool of Biosciences, Faculty of Health and Medical Sciences, Taylor's University (Lakeside Campus) Subang Jaya, Selangor, Malaysia.
Malaysian Palm Oil Board · MYTaylor's University · MYUniversidade de Vigo · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoids (vitamin A) have been reported extensively for anti-cancer properties due to their high receptor-binding affinities and gene regulation abilities. However, the anti-cancer potential of retinoids has not been reviewed in recent years. Thus, this review focused on the anti-cancer effects of retinoids and their synergistic effects with other drugs, together with their mechanisms of action in different types of cancers reported in the past five years. The retinoids were well studied in breast cancer, melanoma, and colorectal cancer. Synthetic retinoids have shown higher selectivity, stronger effectiveness, and lower toxicity than endogenous retinoids. Interestingly, the combination treatment of endogenous retinoids with chemotherapy drugs showed enhanced anti-cancer effects. The mechanisms of action reported for retinoids mainly involved the RAR/RXR signaling pathway. However, limited clinical studies were conducted in recent years. Thus, retinoids which are highly potential anti-cancer agents are worth further study in clinical, especially as a combination therapy with chemotherapy drugs.

Indexed as

All-trans-retinoic acidcombination treatmentRAR/RXR signaling pathwayvitamin A

Identifiers

PMID35411232
PMCPMC8984900
OpenAlexW4225726695

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.