Evidence map›Paper›PMID 35412274›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Studying Axonal Transport in the Brain by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI).

Elaine L Bearer, Xiaowei Zhang, Russell E Jacobs

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Elaine L BearerDepartment Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. ebearer@salud.unm.edu.
Xiaowei ZhangDepartment of Radiology, UC San Diego School of Medicine, San Diego, CA, USA.
Russell E JacobsZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of California, San Diego · USUniversity of New Mexico · USUniversity of Southern California · US

Funding

Live imaging of brain circuitry in mouse models of PTSDR01MH096093 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BEARER, ELAINE L · 2012 to 2016
$2.8M
In Vivo Detection of Neuronal ActivityR01DA018184 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI JACOBS, RUSSELL E · 2006 to 2010
$1.8M
Using Transport to Map the BrainR01NS062184 · NINDS · UNIVERSITY OF NEW MEXICO · PI BEARER, ELAINE L · 2009 to 2010
$1.5M
NIDA NIH HHS R01 DA018184NIMH NIH HHS R01 MH096093NINDS NIH HHS R01 NS062184
6 · The paper itself

Abstract

From the earliest notions of dynamic movements within the cell by Leeuwenhoek, intracellular transport in eukaryotes has been primarily explored by optical imaging. The giant axon of the squid became a prime experimental model for imaging transport due to its size, optical transparency, and physiological robustness. Even the biochemical basis of transport was identified using optical assays based on video microscopy of fractionated squid axoplasm. Discoveries about the dynamics and molecular components of the intracellular transport system continued in many model organisms that afforded experimental systems for optical imaging. Yet whether these experimental systems reflected a valid picture of axonal transport in the opaque mammalian brain was unknown.Magnetic resonance imaging (MRI) provides a non-destructive approach to peer into opaque tissues like the brain . The paramagnetic ion, manganese (MnII), gives a hyperintense signal in T

Indexed as

Axonal TransportManganeseAnimalsBrainBrain MappingMagnetic Resonance ImagingMammalsManganeseAxonal transportIntracellular transportKinesinMagnetic resonance imaging (MRI)ManganeseMicropipettesNeuronal projectionsStatistical parametric mappingStereotactic injectionT1-weighted MRITime-lapse MRITract tracing

Identifiers

PMID35412274
OpenAlexW4225615902

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.