ArticleHuman brain mapping2022
Aberrant dynamic structure-function relationship of rich-club organization in treatment-naïve newly diagnosed juvenile myoclonic epilepsy.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Brain imaging reveals hierarchical topology changes and stage-dependent impairments in autoimmune encephalitis.Journal of neurology · 2026Article
- Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study.BMC medicine · 2025Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Sex effects on dynamic structure-function coupling of intrinsic brain network.Brain imaging and behavior · 2025Article
- Counterfactual explanations of tree based ensemble models for brain disease analysis with structure function coupling.Scientific reports · 2025Article
- Partial correlation as a tool for mapping functional-structural correspondence in human brain connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Structure-function coupling in macroscale human brain networks.Nature reviews. Neuroscience · 2024Review
- Altered effective connectivity of the default mode network in juvenile myoclonic epilepsy.Cognitive neurodynamics · 2024Article
- Hub overload and failure as a final common pathway in neurological brain network disorders.Network neuroscience (Cambridge, Mass.) · 2024Review
- Association study of brain structure-function coupling and glymphatic system function in patients with mild cognitive impairment due to Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Age of Bilingual Onset Shapes the Dynamics of Functional Connectivity and Laterality in the Resting-State.Brain sciences · 2023Article
- Altered Relationship between Functional Connectivity and Fiber-Bundle Structure in High-Functioning Male Adults with Autism Spectrum Disorder.Brain sciences · 2023Article
- Aberrant dynamic Functional-Structural connectivity coupling of Large-scale brain networks in poststroke motor dysfunction.NeuroImage. Clinical · 2023Article
- Aberrant dynamic structure-function relationship of rich-club organization in treatment-naïve newly diagnosed juvenile myoclonic epilepsy.Human brain mapping · 2022Article
- Emotional Blind Spots in Juvenile Myoclonic Epilepsy.Epilepsy currentsArticle
- Juvenile myoclonic epilepsy as a spectrum disorder: mechanisms of drug resistance and precision management.Frontiers in neurologyReview
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging studies have shown that juvenile myoclonic epilepsy (JME) is characterized by impaired brain networks. However, few studies have investigated the potential disruptions in rich-club organization-a core feature of the brain networks. Moreover, it is unclear how structure-function relationships dynamically change over time in JME. Here, we quantify the anatomical rich-club organization and dynamic structural and functional connectivity (SC-FC) coupling in 47 treatment-naïve newly diagnosed patients with JME and 40 matched healthy controls. Dynamic functional network efficiency and its association with SC-FC coupling were also calculated to examine the supporting of structure-function relationship to brain information transfer. The results showed that the anatomical rich-club organization was disrupted in the patient group, along with decreased connectivity strength among rich-club hub nodes. Furthermore, reduced SC-FC coupling in rich-club organization of the patients was found in two functionally independent dynamic states, that is the functional segregation state (State 1) and the strong somatomotor-cognitive control interaction state (State 5); and the latter was significantly associated with disease severity. In addition, the relationships between SC-FC coupling of hub nodes connections and functional network efficiency in State 1 were found to be absent in patients. The aberrant dynamic SC-FC coupling of rich-club organization suggests a selective influence of densely interconnected network core in patients with JME at the early phase of the disease, offering new insights and potential biomarkers into the underlying neurodevelopmental basis of behavioral and cognitive impairments observed in JME.
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