Evidence map›Paper›PMID 35418122›Full record

SynthesisBlood cancer journal2022

Genome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6.

Alyssa Clay-Gilmour, Subhayan Chattopadhyay, Michelle A T Hildebrandt, Hauke Thomsen, Niels Weinhold, Pavel Vodicka, Ludmila Vodickova, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel and 17 more

Abstract readLetterMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Blood cancer journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Alyssa Clay-Gilmour *Arnold School of Public Health, Department of Epidemiology & Biostatistics, University of South Carolina, Columbia, SC, USA.
Subhayan Chattopadhyay *Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Michelle A T HildebrandtDepartment of Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hauke ThomsenGeneWerk GmbH, Im Neuenheimer Feld 582, 6910, Heidelberg, Germany.ORCID 0000-0001-5951-3116
Niels WeinholdDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Pavel VodickaInstitute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic.
Ludmila VodickovaInstitute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic.
Per HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID 0000-0002-8770-2464
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
Börge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
Christian LangerDepartment of Internal Medicine III, University of Ulm, Ulm, Germany.
Roman HajekDepartment of Hematooncology, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.ORCID 0000-0001-6955-6267
Göran HallmansDepartment of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
Ulrika Pettersson-KymmerClinical Pharmacology, Department of Integrative Medical Biology, Umea University, Umea, Sweden.ORCID 0000-0002-0557-9803
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Florentin SpäthDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Richard HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.ORCID 0000-0002-5268-0242
Hartmut GoldschmidtDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-0961-0035
Elisabet E ManasanchDepartment of Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-0857-176X
Aaron NormanDivision of Computational Genomics, Mayo Clinic, Rochester, MN, USA.
Shaji KumarDivision of Hematology, Mayo Clinic Rochester Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5392-9284
S Vincent RajkumarDivision of Hematology, Mayo Clinic Rochester Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5862-1833
Susan SlagerDivision of Computational Genomics, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5173-4712
Asta FörstiHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Celine M Vachon *Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. vachon.celine@mayo.edu.ORCID 0000-0002-1962-9322
Kari Hemminki *Biomedical Center, Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, 30605, Pilsen, Czech Republic.

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Yi Lin · 2015 to 2026
$25.5M
Mayo Cancer Genetic Epidemiology Training ProgramR25CA092049 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M., VACHON, CELINE M · 2001 to 2018
$5.3M
Onset and biomarkers for progression of monoclonal gammopathiesR01CA168762 · NCI · MAYO CLINIC ROCHESTER · PI KUMAR, SHAJI KUNNATHU, RAJKUMAR, S VINCENT · 2012 to 2024
$3.2M
InterLymph Consortium: interrogating pleiotropy and gene by environment interactions among hematopoietic malignancies.U01CA257679 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI CLAY-GILMOUR, ALYSSA IONE, HJALGRIM, HENRIK · 2021 to 2025
$2.7M
NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA186781NCI NIH HHS R01 CA168762NCI NIH HHS R25 CA092049NCI NIH HHS U01 CA257679
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Monoclonal Gammopathy of Undetermined SignificanceParaproteinemiasHumans

Identifiers

PMID35418122
PMCPMC9007981

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.