ArticleScientific reports2022
Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation.
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Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- PET Imaging in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
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- Immuno-imaging in solid organ transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- Molecular imaging of immune and fibrosis targets to guide therapy for repair after myocardial infarction.Nature reviews. Cardiology · 2026Review
- From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026Review
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- A Comprehensive Review of SSTR-Based Spect and Pet Imaging in Chronic Inflammatory and Immune-Mediated Diseases.Journal of clinical medicine · 2025Review
- The Development and Challenges of PET/MRI Dual-Modality Imaging Probes-An Update.Journal of magnetic resonance imaging : JMRI · 2025Review
- Inflammation reprogramming and immunomodulation: Next-generation treatments for atherosclerosis.Cell reports. Medicine · 2025Review
- Hybrid PET/MRI in Inflammatory Cardiac Diseases: A Systematic Review and Single-Center Experience.Diagnostics (Basel, Switzerland) · 2025Review
- Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases.Circulation research · 2025Review
- Meningioma: Novel Diagnostic and Therapeutic Approaches.Biomedicines · 2025Review
- Prognostic value ofFrontiers in cardiovascular medicine · 2025Article
- Uncovering atherosclerotic cardiovascular disease by PET imaging.Nature reviews. Cardiology · 2024Review
- Detection of infective endocarditis with [European heart journal. Case reports · 2024Article
- Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer.Npj imaging · 2024Article
- Radiotracers for Imaging of Inflammatory Biomarkers TSPO and COX-2 in the Brain and in the Periphery.International journal of molecular sciences · 2023Review
- Imaging Inflammation Past, Present, and Future: Focus on Cardioimmunology.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Highlighting Fibroblasts Activation in Fibrosis: The State-of-The-Art Fibroblast Activation Protein Inhibitor PET Imaging in Cardiovascular Diseases.Journal of clinical medicine · 2023Review
- Review
Corrections and comments
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Authors and funding
26 authors at 12 institutions in 7 countries.
Yohana C Toner *BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Adam A Ghotbi *BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Sonum NaiduBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Ken SakuraiBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Mandy M T van LeentBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Stefan JordanDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Farideh OrdikhaniDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Letizia AmadoriDepartment of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexandros Marios SofiasBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Elizabeth L FisherBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Alexander MaierBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Nathaniel SullivanBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Jazz MunitzBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Max L SendersBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Christian MasonDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Thomas ReinerDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Georgios SoultanidisBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Jason M TarkinDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
James H F RuddDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
Chiara GiannarelliDepartment of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jordi OchandoDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carlos Pérez-MedinaBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Andreas KjaerDepartment of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Willem J M MulderBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Zahi A FayadBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA.
Claudia CalcagnoBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, PO Box: 1234, New York, NY, 10029, USA. claudia.calcagno@mssm.edu.
Icahn School of Medicine at Mount Sinai · USNew York University · USUniversity of Cambridge · GBCornell University · USEindhoven University of Technology · NLMemorial Sloan Kettering Cancer Center · USNorwegian University of Science and Technology · NORadboud University Nijmegen · NLRigshospitalet · DKSpanish National Centre for Cardiovascular Research · ESUniversity of Copenhagen · DKUniversity of Freiburg · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MTRAINING PROGRAM IN CANCER THERAPYT32CA078207 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI James J Manfredi · 1999 to 2026
$11.6MAtherosclerosis in cocaine addiction: imaging risk with PET/MRR01DA049547 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Nelly Alia-Klein, Zahi A. Fayad · 2022 to 2026
$3.9MDissecting the role of CD8+ T cells in atherosclerosisR01HL153712 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GIANNARELLI, CHIARA · 2020 to 2024
$3.3MGa68-DOTATATE PET imaging of plaque inflammationR01HL135878 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2017 to 2020
$2.9MSingle-cell-driven drug repositioning approaches to target inflammation in atherosclerosisUH3TR002067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GIANNARELLI, CHIARA · 2019 to 2019
$170kAmerican Heart Association-American Stroke Association 20SFRN35210252British Heart Foundation CH/10/001/27642British Heart Foundation FS/12/29/29463Department of HealthMedical Research Council MR/N028015/1NCATS NIH HHS UH3 TR002067NCATS NIH HHS UH3TR002067NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA078207NHLBI NIH HHS R01 HL135878NHLBI NIH HHS R01 HL153712NHLBI NIH HHS R01 HL153712-01NIDA NIH HHS R01 DA049547NIH HHS T32CA078207Wellcome TrustWellcome Trust 211100/Z/18/Z
Abstract
In recent years, cardiovascular immuno-imaging by positron emission tomography (PET) has undergone tremendous progress in preclinical settings. Clinically, two approved PET tracers hold great potential for inflammation imaging in cardiovascular patients, namely FDG and DOTATATE. While the former is a widely applied metabolic tracer, DOTATATE is a relatively new PET tracer targeting the somatostatin receptor 2 (SST2). In the current study, we performed a detailed, head-to-head comparison of DOTATATE-based radiotracers and [
Indexed as
AtherosclerosisMyocardial InfarctionOrganometallic CompoundsAnimalsFluorodeoxyglucose F18Gallium RadioisotopesHumansInflammationMicePositron-Emission TomographyPositron Emission Tomography Computed TomographyRabbitsRadionuclide ImagingRadiopharmaceuticalsTissue Distributioncopper dotatate CU-64Fluorodeoxyglucose F18Gallium RadioisotopesOrganometallic CompoundsRadiopharmaceuticals
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.