Evidence map›Paper›PMID 35420372›Full record

ReviewCurrent rheumatology reports2022

Autonomic Nervous System Dysregulation and Osteoarthritis Pain: Mechanisms, Measurement, and Future Outlook.

Taylor D Yeater, Carlos J Cruz, Yenisel Cruz-Almeida, Kyle D Allen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current rheumatology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Taylor D YeaterJ. Crayton Pruitt Family Department of Biomedical Engineering, Biomedical Sciences Building, University of Florida, 1275 Center Drive, Gainesville, FL, 32610, USA.
Carlos J CruzJ. Crayton Pruitt Family Department of Biomedical Engineering, Biomedical Sciences Building, University of Florida, 1275 Center Drive, Gainesville, FL, 32610, USA.
Yenisel Cruz-AlmeidaPain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.
Kyle D AllenJ. Crayton Pruitt Family Department of Biomedical Engineering, Biomedical Sciences Building, University of Florida, 1275 Center Drive, Gainesville, FL, 32610, USA. kyle.allen@bme.ufl.edu.

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Todd Manini · 2007 to 2026
$22.8M
OA Pathogenesis beyond Cartilage: A preclinical study of the sources of OA painR01AR071431 · NIAMS · UNIVERSITY OF FLORIDA · PI ALLEN, KYLE D · 2018 to 2022
$2.3M
Investigating the role of osteoarthritic pain and inflammation in autonomic nervous system shifts using preclinical modelsF31AR077996 · NIAMS · UNIVERSITY OF FLORIDA · PI YEATER, TAYLOR · 2020 to 2021
$80k
NIAMS NIH HHS F31 AR077996NIAMS NIH HHS R01 AR071431NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

purpose of reviewThe autonomic nervous system is an important regulator of stress responses and exhibits functional changes in chronic pain states. This review discusses potential overlap among autonomic dysregulation, osteoarthritis (OA) progression, and chronic pain. From this foundation, we then discuss preclinical to clinical research opportunities to close gaps in our knowledge of autonomic dysregulation and OA. Finally, we consider the potential to generate new therapies for OA pain via modulation of the autonomic nervous system. RECENT

findingsRecent reviews provide a framework for the autonomic nervous system in OA progression; however, research is still limited on the topic. In other chronic pain states, functional overlaps between the central autonomic network and pain processing centers in the brain suggest relationships between concomitant dysregulation of the two systems. Non-pharmacological therapeutics, such as vagus nerve stimulation, mindfulness-based meditation, and exercise, have shown promise in alleviating painful symptoms of joint diseases, and these interventions may be partially mediated through the autonomic nervous system. The autonomic nervous system appears to be dysregulated in OA progression, and further research on rebalancing autonomic function may lead to novel therapeutic strategies for treating OA pain.

Indexed as

Chronic PainOsteoarthritisAutonomic Nervous SystemHumansAutonomic nervous systemNeuro-immune axisOsteoarthritisPain

Identifiers

PMID35420372
PMCPMC9189055

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.