ArticleRSC advances2022
Effect of crystallinity and related surface properties on gene expression of primary fibroblasts.
Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
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- Amphiphilic Thermoresponsive Triblock PLA-PEG-PLA and Diblock mPEG-PLA Copolymers for Controlled Deferoxamine Delivery.Gels (Basel, Switzerland) · 2025Article
- A novel fully biobased material composite for cosmetic packaging applications.Scientific reports · 2025Article
- Designing Smartly: Understanding the Crystallinity of Melt Electrowritten Scaffolds.Engineering in life sciences · 2025Article
- On the Structural and Biological Effects of Hydroxyapatite and Gold Nano-Scale Particles in Poly(Vinylidene Fluoride) Smart Scaffolds for Bone and Neural Tissue Engineering.Molecules (Basel, Switzerland) · 2025Article
- Crystallinity of covalent organic frameworks controls immune responses.Nature communications · 2024Article
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- Biobran-loaded core/shell nanofibrous scaffold: a promising wound dressing candidate.RSC advances · 2024Article
- Chitosan-Based High-Intensity Modification of the Biodegradable Substitutes for Cancellous Bone.Journal of functional biomaterials · 2023Article
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- PCL and DMSOMaterials (Basel, Switzerland) · 2023Article
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- Immobilization of Gelatin on Fibers for Tissue Engineering Applications: A Comparative Study of Three Aliphatic Polyesters.Polymers · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biomaterial-cells interface is one of the most fundamental issues in tissue regeneration. Despite many years of scientific work, there is no clear answer to what determines the desired adhesion of cells and the synthesis of ECM proteins. Crystallinity is a characteristic of the structure that influences the surface and bulk properties of semicrystalline polymers used in medicine. The crystallinity of polycaprolactone (PCL) was varied by changing the molecular weight of the polymer and the annealing procedure. Measurements of surface free energy showed differences related to substrate crystallinity. Additionally, the water contact angle was determined to characterise surface wettability which was crucial in the analysis of protein absorption. X-ray photoelectron spectroscopy was used to indicate oxygen bonds amount on the surface. Finally, the impact of the crystallinity, and related properties were demonstrated on dermal fibroblasts' response. Cellular proliferation and expression of selected genes: α-SMA, collagen I, TIMP, integrin were analysed.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.