ArticleDisease markers2022
lncRNA CDKN2B-AS1 Could Be an Indicator to Identify Prognosis and Status of Immune Microenvironment in Thyroid Cancer.
Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- lncRNA ACVR2B-AS1 modulates thyroid cancer progression by regulating miR-195-5p.Discover oncology · 2025Article
- Associations of the Expression Levels and Risk Variants of CDKN2B-AS1 Long Noncoding RNA With the Susceptibility and Progression of Prostate Cancer.Journal of cellular and molecular medicine · 2024Article
- The Long Non-Coding RNA ANRIL in Cancers.Cancers · 2023Review
- Cuproptosis-related gene SLC31A1 is a potential predictor for diagnosis, prognosis and therapeutic response of breast cancer.American journal of cancer research · 2022Article
- Predicting prognosis and immunotherapeutic response of clear cell renal cell carcinoma.Frontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid cancer (TC) is prone to recurrence, and biomarkers for predicting progression-free interval (PFI) are poorly explored. The study investigates the predictive value and underlying biological mechanisms of lncRNA CDKN2B-AS1 in TC. Combining RNA-seq and survival data, we identified that CDKN2B-AS1 was upregulated in TC samples and could be an excellent prognostic indicator. To exclude confounding factors, we divided patients into different subgroups using median CDKN2B-AS1 expression, and the effects of CDKN2B-AS1 on PFI and clinical features were explored in different clinical subgroups. Meanwhile, ssGSEA and ESTIMATE algorithms revealed that CDKN2B-AS1 overexpression may suggest the active state of the immune microenvironment. On the other hand, enrichment analysis also proved the potential influence of CDKN2B-AS1 on immune regulation in TC. Finally, we created a CDKN2B-AS1, microRNAs, and TFs network and discovered a new biomarker (CDKN2B-AS1) that might be employed as a therapeutic target in TC patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.