Evidence map›Paper›PMID 35436329›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2022

Effect of High-Intensity Power Training on Cognitive Function in Older Adults With Type 2 Diabetes: Secondary Outcomes of the GREAT2DO Study.

Ren Ru Zhao, Yorgi Mavros, Jacinda Meiklejohn, Kylie A Anderberg, Nalin Singh, Shelley Kay, Michael K Baker, Yi Wang, Mike Climstein, Anthony O'Sullivan and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ren Ru ZhaoExercise Health and Performance Faculty Research Group, Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, New South Wales, Australia.ORCID 0000-0001-5805-8043
Yorgi MavrosExercise Health and Performance Faculty Research Group, Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, New South Wales, Australia.ORCID 0000-0002-2588-0425
Jacinda MeiklejohnExercise Health and Performance Faculty Research Group, Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, New South Wales, Australia.
Kylie A AnderbergExercise Health and Performance Faculty Research Group, Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, New South Wales, Australia.
Nalin SinghExercise Health and Performance Faculty Research Group, Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, New South Wales, Australia.
Shelley KayCentre for Medical Psychology and Evidence Based Decision Making, Faculty of Medicine, University of Sydney, Camperdown, Sydney, New South Wales, Australia.
Michael K BakerResearch Ethics and Integrity, Australian Catholic University, Strathfield, New South Wales, Australia.
Yi WangLipid Metabolism and Cardiometabolic Disease Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Mike ClimsteinSchool of Health and Human Sciences, Southern Cross University, Gold Coast, Queensland, Australia.
Anthony O'SullivanDepartment of Endocrinology, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Nathan De VosThe Centre for STRONG Medicine, Balmain Hospital, Sydney, New South Wales, Australia.
Bernhard T BauneDepartment of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.
Steven N BlairExercise Science Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
David SimarSchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Maria A Fiatarone SinghExercise Health and Performance Faculty Research Group, Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, New South Wales, Australia.

Funding

Australian Diabetes Society and Diabetes AustraliaNational Health and Medical Research Council
6 · The paper itself

Abstract

We sought to determine the effects of 12 months of power training on cognition, and whether improvements in body composition, muscle strength, and/or aerobic capacity (VO2peak) were associated with improvements in cognition in older adults with type 2 diabetes (T2D). Participants with T2D were randomized to power training or low-intensity sham exercise control condition, 3 days per week for 12 months. Cognitive outcomes included memory, attention/speed, executive function, and global cognition. Other relevant outcomes included VO2peak, strength, and whole body and regional body composition. One hundred and three adults with T2D (mean age 67.9 years; standard deviation [SD] 5.9; 50.5% women) were enrolled and analyzed. Unexpectedly, there was a nearly significant improvement in global cognition (p = .05) in the sham group relative to power training, although both groups improved over time (p < .01). There were significant interactions between group allocation and body composition or muscle strength in the models predicting cognitive changes. Therefore, after stratifying by group allocation, improvements in immediate memory were associated with increases in relative skeletal muscle mass (r = 0.38, p = .03), reductions in relative body fat (r = -0.40, p = .02), and increases in knee extension strength were directly related to changes in executive function (r = -0.41, p = .02) within the power training group. None of these relationships were present in the sham group (p > .05). Although power training did not significantly improve cognition compared to low-intensity exercise control, improvements in cognitive function in older adults were associated with hypothesized improvements in body composition and strength after power training.

Indexed as

CognitionDiabetes Mellitus, Type 2Resistance TrainingAgedBody CompositionFemaleHumansMaleMuscle StrengthCognitionPower trainingType 2 diabetes

Identifiers

PMID35436329
PMCPMC9536451

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.