Evidence map›Paper›PMID 35440891›Full record

ArticleGenetics research2022

Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034.

Maricela Aceves-Ramírez, Yeminia Valle, Fidel Casillas-Muñoz, Diana Emilia Martínez-Fernández, Brenda Parra-Reyna, Víctor Arturo López-Moreno, Héctor Enrique Flores-Salinas, Emmanuel Valdés-Alvarado, José Francisco Muñoz-Valle, Texali García-Garduño and 1 more

Open access · goldAbstract read
In one paragraph

Article in Genetics research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Population Admixture andJournal of cardiovascular development and disease · 2026
    Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Maricela Aceves-RamírezInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0003-1779-9659
Yeminia ValleInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0002-4940-022X
Fidel Casillas-MuñozInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0003-1969-3516
Diana Emilia Martínez-FernándezInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0002-3640-4870
Brenda Parra-ReynaInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0003-2653-0301
Víctor Arturo López-MorenoEspecialidad en Cardiología, Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente (CMNO), Departamento de Cardiología, Instituto Mexicano Del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
Héctor Enrique Flores-SalinasEspecialidad en Cardiología, Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente (CMNO), Departamento de Cardiología, Instituto Mexicano Del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
Emmanuel Valdés-AlvaradoInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0001-6810-9203
José Francisco Muñoz-ValleInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0002-2272-9260
Texali García-GarduñoInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0002-7564-4877
Jorge Ramón Padilla-GutiérrezInstituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud (CUCS), Universidad de Guadalajara (UDG), Guadalajara, Jalisco, Mexico.ORCID 0000-0002-0240-2797
Universidad de Guadalajara · MXMexican Social Security Institute · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apolipoprotein B (APOB) is associated with the development of atherosclerosis and consequently in the acute coronary syndrome (ACS) physiopathology. Single number variants (SNVs) in apolipoprotein B gene (APOB) influence over the susceptibility for this syndrome. The aim of this study was to determine the impact of the rs1469513, rs673548, rs676210, and rs1042034 SNVs and serum levels of APOB in the risk of ACS in a population from western Mexico. We included 300 patients in the group of cases (ACSG) and 300 individuals in the control group (CG). APOB levels were evaluated by immunonephelometry, and SNVs were genotyped with TaqMan probes. We found significant allelic and genotypic differences between groups for rs673548 and rs676210 (OR = 1.33,

Indexed as

Acute Coronary SyndromeApolipoproteins BHumansMexicoNucleotidesPolymorphism, Single NucleotideApolipoproteins BNucleotides

Identifiers

PMID35440891
PMCPMC8991409
OpenAlexW4220691596

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.