Evidence map›Paper›PMID 35441138›Full record

ArticleNeuro-oncology advances

Filamin A increases aggressiveness of human neuroblastoma.

Sashidar Bandaru, Bharat Prajapati, Prasanna Kumar Juvvuna, Sandor Dosa, Per Kogner, John I Johnsen, Chandrasekhar Kanduri, Levent M Akyürek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sashidar BandaruDepartment of Clinical Pathology, Sahlgrenska University Hospital, Region Västra Götaland, Göteborg, Sweden.
Bharat PrajapatiDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden.
Prasanna Kumar JuvvunaDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden.
Sandor DosaDepartment of Clinical Pathology, Sahlgrenska University Hospital, Region Västra Götaland, Göteborg, Sweden.
Per KognerChildhood Cancer Research Unit, Department of Women´s and Children's Health, Karolinska Institute, Stockholm, Sweden.
John I JohnsenChildhood Cancer Research Unit, Department of Women´s and Children's Health, Karolinska Institute, Stockholm, Sweden.
Chandrasekhar KanduriDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden.
Levent M AkyürekDepartment of Clinical Pathology, Sahlgrenska University Hospital, Region Västra Götaland, Göteborg, Sweden.ORCID https://orcid.org/0000-0002-1968-6458
Sahlgrenska University Hospital · SEUniversity of Gothenburg · SEKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The actin-binding protein filamin A (FLNA) regulates oncogenic signal transduction important for tumor growth, but the role of FLNA in the progression of neuroblastoma (NB) has not been explored. Methods: We analyzed Results: We observed shorter patient survival with higher expression of Conclusion: Inhibition of FLNA impaired NB cell signaling and function and reduced NB tumor size

Indexed as

filaminhigh-riskMYCNneuroblastomaSTAT3

Identifiers

PMID35441138
PMCPMC9012446
OpenAlexW4214722320

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.