Evidence map›Paper›PMID 35444778›Full record

ArticleJournal of healthcare engineering2022

The Value of Serum Exosomal miR-184 in the Diagnosis of NSCLC.

Shujun Li, Yanming Lin, Yanxia Wu, Hualin Chen, Zhong Huang, Muwen Lin, Jiali Dong, Yongcun Wang, Zhixiong Yang

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. The diagnostic and prognostic value of exosomal microRNAs in lung cancer: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

  • Retraction · 2023-08-16Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Informed/Patient Consent - None/Withdrawn · Investigation by Journal/Publisher · Investigation by Third Party · Lack of IRB/IACUC Approval and/or Compliance · Paper Mill · Computer-Aided Content or Computer-Generated Content · Unreliable Results and/or Conclusions ·
  • Retracted
5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shujun LiDepartment of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.
Yanming LinDepartment of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.
Yanxia WuGuangdong Medical University Affiliated Pathology Diagnosis and Research Center, Zhanjuang 524023, China.
Hualin ChenDepartment of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.
Zhong HuangDepartment of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.
Muwen LinDepartment of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.
Jiali DongDepartment of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.
Yongcun WangDepartment of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.ORCID 0000-0002-1278-7942
Zhixiong YangDepartment of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China.
Guangdong Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer has the highest morbidity rate (11.6%) and mortality rate (18.4%) among all current tumors. The morbidity rate in China accounts for approximately one-third, and it is still rising. Nonsmall cell lung cancer is the most common type of lung cancer, accounting for 80%-85% of all lung cancers, and approximately 57% of patients with advanced nonsmall cell lung cancer have distant metastases at the time of diagnosis. To explore the expression changes in microRNA-184 (miR-184) and its clinical value in serum exosomes of patients with nonsmall cell lung cancer (NSCLC). This study adopted a case-control study method, selecting 88 patients (NSCLC group) from June 2015 to June 2017 in our hospital who are confirmed to have NSCLC by fiber-optic bronchoscopy, and 90 patients who are confirmed to have benign lung diseases by pathological examination during the same period (control group). Fluorescence quantitative PCR technology is used to detect the levels of miR-184 in serum exosomes of the two groups, and the differences in the levels of miR-184 in serum exosomes of NSCLC patients with different pathological characteristics are analyzed. According to the results of the 3-year follow-up, the miR-184 levels in serum exosomes of NSCLC patients are grouped and compared. The expression level of miR-184 in serum exosomes in the NSCLC group is significantly higher than that in the control group, and the difference between the two groups is statistically significant (

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsMicroRNAsBiomarkers, TumorCase-Control StudiesHumansBiomarkers, TumorMicroRNAsMIRN184 microRNA, human

Identifiers

PMID35444778
PMCPMC9015881
OpenAlexW4223451440

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.