Evidence map›Paper›PMID 35447347›Full record

ArticleRespiratory physiology & neurobiology2022

D-cysteine ethyl ester and D-cystine dimethyl ester reverse the deleterious effects of morphine on arterial blood-gas chemistry and Alveolar-arterial gradient in anesthetized rats.

Paulina M Getsy, Alex P Young, Alan Grossfield, James M Seckler, Christopher G Wilson, Benjamin Gaston, James N Bates, Stephen J Lewis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

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  12. L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Article
  13. Thoughts on the role of endogenous D-cysteine in neuronal function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Paulina M GetsyDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: pxg55@case.edu.
Alex P YoungPediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Alan GrossfieldDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA.
James M SecklerDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Christopher G WilsonBasic Sciences, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Benjamin GastonHerman B Wells Center for Pediatric Research, Indiana University, School of Medicine Indianapolis, IN 46202, USA.
James N BatesDepartment of Anesthesiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Stephen J LewisDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA; Functinal Electrical Stimulation Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Case Western Reserve University · USIndiana University – Purdue University Indianapolis · USLoma Linda University · USUniversity of Iowa Hospitals and Clinics · USUniversity of Rochester Medical Center · USUniversity of Virginia · US

Funding

Project 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2M
S-nitrosothiol signaling in pulmonary epithelial cellsP01HL101871 · NHLBI · UNIVERSITY OF VIRGINIA · PI GASTON, BENJAMIN, LEWIS, STEPHEN JOHN · 2011 to 2015
$8.7M
Optimization of novel thioesters as a therapeutic strategy for combating opioid overdoses and abuseU01DA051373 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI LEWIS, STEPHEN JOHN · 2020 to 2022
$1.5M
Sudaxine as an analgesia sparing respiratory stimulant for use in critical careR61HL154136 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, LEWIS, STEPHEN JOHN · 2020 to 2021
$1.1M
Sudaxine as an analgesia sparing respiratory stimulant for use in critical careR33HL154136 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, LEWIS, STEPHEN JOHN · 2022 to 2022
$557k
NHLBI NIH HHS P01 HL101871NHLBI NIH HHS P01 HL128192NHLBI NIH HHS R33 HL154136NHLBI NIH HHS R61 HL154136NIDA NIH HHS U01 DA051373
6 · The paper itself

Abstract

We determined whether intravenous injections of the membrane-permeable ventilatory stimulants, D-cysteine ethyl ester (ethyl (2 S)- 2-amino-3-sulfanylpropanoate) (D-CYSee) and D-cystine dimethyl ester (methyl (2 S)- 2-amino-3-[[(2 S)- 2-amino-3-methoxy-3-oxopropyl]disulfanyl] propanoate) (D-CYSdime), could overcome the deleterious actions of intravenous morphine on arterial blood pH, pCO

Indexed as

CystineMorphineAnimalsCysteineRatsRats, Sprague-DawleyCysteineCystinecystine dimethyl esterethyl cysteineMorphineAnesthetized ratsArterial blood gasesD-cysteine ethyl esterD-cystine dimethyl esterMorphine

Identifiers

PMID35447347
PMCPMC9588175
OpenAlexW4224039333

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.