Evidence mapPaperPMID 35448312Full record

ReviewBiosensors2022

Nanomaterial-Based Label-Free Electrochemical Aptasensors for the Detection of Thrombin.

Hibba Yousef, Yang Liu, Lianxi Zheng

Abstract readReview
In one paragraph

Review in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hibba YousefDepartment of Biomedical Engineering, Khalifa University, Abu Dhabi 127788, United Arab Emirates.
Yang LiuCollege of Science and Engineering, James Cook University, Townsville, QLD 4811, Australia.ORCID 0000-0003-2085-5148
Lianxi ZhengDepartment of Mechanical Engineering, Khalifa University, Abu Dhabi 127788, United Arab Emirates.ORCID 0000-0003-4974-365X

Funding

Khalifa University of Science and Technology CIRA-2020-024
6 · The paper itself

Abstract

Thrombin plays a central role in hemostasis and its imbalances in coagulation can lead to various pathologies. It is of clinical significance to develop a fast and accurate method for the quantitative detection of thrombin. Electrochemical aptasensors have the capability of combining the specific selectivity from aptamers with the extraordinary sensitivity from electrochemical techniques and thus have attracted considerable attention for the trace-level detection of thrombin. Nanomaterials and nanostructures can further enhance the performance of thrombin aptasensors to achieve high sensitivity, selectivity, and antifouling functions. In highlighting these material merits and their impacts on sensor performance, this paper reviews the most recent advances in label-free electrochemical aptasensors for thrombin detection, with an emphasis on nanomaterials and nanostructures utilized in sensor design and fabrication. The performance, advantages, and limitations of those aptasensors are summarized and compared according to their material structures and compositions.

Indexed as

Aptamers, NucleotideBiosensing TechniquesNanostructuresElectrochemical TechniquesThrombinAptamers, NucleotideThrombinaptasensorelectrochemicallabel freenanomaterialthrombin

Identifiers

PMID35448312
PMCPMC9025199

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.