Evidence map›Paper›PMID 35448585›Full record

ArticleJournal of fungi (Basel, Switzerland)2022

Protein Kinase A Regulates Autophagy-Associated Proteins Impacting Growth and Virulence of

E Keats Shwab, Praveen R Juvvadi, Shareef K Shaheen, John Allen, Greg Waitt, Erik J Soderblom, Yohannes G Asfaw, M Arthur Moseley, William J Steinbach

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Multifunctional Roles of Autophagy in Fungi.Journal of fungi (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Shining a light on the impact of antifungals onAntimicrobial agents and chemotherapy · 2024
    Article
  5. The Sorting Nexin GenesJournal of fungi (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

E Keats ShwabDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-8383-1031
Praveen R JuvvadiDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Shareef K ShaheenDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
John AllenDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Greg WaittDuke Proteomics Core Facility, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27701, USA.
Erik J SoderblomDuke Proteomics Core Facility, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27701, USA.
Yohannes G AsfawDepartment of Laboratory Animal Resources, Duke University Medical Center, Durham, NC 27710, USA.
M Arthur MoseleyDuke Proteomics Core Facility, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27701, USA.
William J SteinbachDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Duke Medical Center · USDuke University · US

Funding

Phosphoproteomic identification of Aspergillus fumigatus virulence-associated protein kinase A downstream effectorsR21AI132911 · NIAID · DUKE UNIVERSITY · PI JUVVADI, PRAVEEN RAO, STEINBACH, WILLIAM J · 2018 to 2019
$440k
National Institute of Allergy and Infectious Diseases 5R21AI132911-02NIAID NIH HHS R21 AI132911
6 · The paper itself

Abstract

Cellular recycling via autophagy-associated proteins is a key catabolic pathway critical to invasive fungal pathogen growth and virulence in the nutrient-limited host environment. Protein kinase A (PKA) is vital for the growth and virulence of numerous fungal pathogens. However, the underlying basis for its regulation of pathogenesis remains poorly understood in any species. Our

Indexed as

aspergillosisAspergillusautophagycell wallfilamentous funginutrient sensingpathogenesisphosphorylationprotein kinase Aproteomics

Identifiers

PMID35448585
PMCPMC9029100
OpenAlexW4220669013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.