Evidence map›Paper›PMID 35448638›Full record

ArticleJournal of fungi (Basel, Switzerland)2022

Heterologous Synthesis of Monacolin J by Reconstructing Its Biosynthetic Gene Cluster in

Xu Zeng, Junwei Zheng, Feifei Lu, Li Pan, Bin Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Systems Biology in Fungal Research.Journal of fungi (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xu ZengSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu Town, Guangzhou 510006, China.
Junwei ZhengSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu Town, Guangzhou 510006, China.
Feifei LuSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu Town, Guangzhou 510006, China.
Li PanSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu Town, Guangzhou 510006, China.
Bin WangSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu Town, Guangzhou 510006, China.
South China University of Technology · CN

Funding

National Key Research and Development Program of China 2021YFC2100200National Natural Science Foundation of China 31870024Natural Science Foundation of Guangdong Province 2019A1515010065R&D projects in key areas of Guangdong Province 2020B020226007
6 · The paper itself

Abstract

Monacolin J (MJ), a key precursor of Lovastatin, could synthesize important statin drug simvastatin by hydrolyzing lovastatin and adding different side chains. In this study, to reduce the cumbersome hydrolysis of lovastatin to produce MJ in the native strain

Indexed as

Aspergillus nigerCRISPR/Cas9 homology-directed recombination (CRISPR-HDR)heterologous synthesisMonacolin Jreconstruction of the biosynthetic gene cluster

Identifiers

PMID35448638
PMCPMC9032219
OpenAlexW4223967625

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.