Evidence map›Paper›PMID 35449947›Full record

ArticleACS omega2022

Polyphenol-Rich Extracts of Xylopia and Aframomum Species Show Metabolic Benefits by Lowering Hepatic Lipid Accumulation in Diet-Induced Obese Mice.

Achille Parfait Nwakiban Atchan, Shilpa Talkad Shivashankara, Stefano Piazza, Armelle Deutou Tchamgoue, Giangiacomo Beretta, Mario Dell'Agli, Paolo Magni, Gabriel Agbor Agbor, Jules-Roger Kuiaté, Uma Venkateswaran Manjappara

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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  7. Frontiers in pharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Achille Parfait Nwakiban AtchanDepartment of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 96, Dschang 67, Cameroon.ORCID https://orcid.org/0000-0003-1660-7125
Shilpa Talkad ShivashankaraDepartment of Lipid Science, CSIR-Central Food Technological Research Institute (CFTRI), Mysore 570 020, India.
Stefano PiazzaDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan 20133, Italy.
Armelle Deutou TchamgoueCentre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, P.O. Box 13033, Yaoundé 13033, Cameroon.
Giangiacomo BerettaDepartment of Environmental Science and Policy, Università degli Studi di Milano, Milan 20133, Italy.
Mario Dell'AgliDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan 20133, Italy.
Paolo MagniDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan 20133, Italy.
Gabriel Agbor AgborCentre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, P.O. Box 13033, Yaoundé 13033, Cameroon.
Jules-Roger KuiatéDepartment of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 96, Dschang 67, Cameroon.
Uma Venkateswaran ManjapparaDepartment of Lipid Science, CSIR-Central Food Technological Research Institute (CFTRI), Mysore 570 020, India.ORCID https://orcid.org/0000-0002-3209-1205
University of Milan · ITCentral Food Technological Research Institute · INInstitut de Recherches Médicales et d’Etudes des Plantes Médicinales · CMUniversité de Dschang · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic syndrome is a complex condition associated with a series of pathologies featuring glucose intolerance, diabetes, high blood pressure, dyslipidemia, microalbuminuria, overweight, and obesity. It is also related to nonalcoholic fatty liver disease (NAFLD), recognized as the most familiar cause of chronic liver disease worldwide. The overall prevalence of metabolic syndrome and, consequently, the one of NAFLD is constantly increasing worldwide. The initial management of these diseases involves lifestyle modifications, including changes in diet and physical exercise. In addition to conventional drugs like orlistat, botanicals are traditionally used to counteract these disorders, and some of them are currently under evaluation. The present work evaluated the in vivo beneficial effects of hydroalcoholic extracts of two Cameroonian spices, focusing on obesity-related hepatic lipid injury in high-fat-fed C57BL/6 mice. Hydroethanolic extracts were prepared and characterized by reverse phase-high-performance liquid chromatography (HPLC)-photodiode array detection and ultra performance liquid chromatography-triple time-of-flight electrospray ionization tandem mass spectroscopy (TOF-ESI-MS/MS) analysis. Plant extracts were orally administered for 30 days at different dose levels (100 and 200 mg kg

Identifiers

PMID35449947
PMCPMC9016817
OpenAlexW4220843205

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.