Evidence map›Paper›PMID 35451663›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Italian translation and validation of fatigue symptoms and impacts questionnaire in relapsing multiple sclerosis (FSIQ-RMS).

Ilaria Ruotolo, Giovanni Sellitto, Antonio Ianniello, Nikolaos Petsas, Letizia Castelli, Giovanni Galeoto, Anna Berardi, Valeria Barletta, Antonella Conte, Carlo Pozzilli

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilaria RuotoloMS Center, S. Andrea Hospital, Sapienza University, Rome, Italy. ilariaruotolo9696@gmail.com.ORCID http://orcid.org/0000-0003-0817-9714
Giovanni SellittoMS Center, S. Andrea Hospital, Sapienza University, Rome, Italy.
Antonio IannielloDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Nikolaos PetsasIRCCS Neuromed, Pozzilli, Italy.
Letizia CastelliFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Giovanni GaleotoDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Anna BerardiDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Valeria BarlettaDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Antonella ConteDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Carlo PozzilliMS Center, S. Andrea Hospital, Sapienza University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatigue is a disabling symptom of multiple sclerosis (MS) and impacts on daily life. The Fatigue Symptoms and Impacts Questionnaire-Relapsing Multiple Sclerosis (FSIQ-RMS) is a new 20-item tool that investigates the aspects of fatigue in MS. It concerns motor, cognitive, social, and emotional aspects of fatigue. We aim at validating the Italian version of FSIQ-RMS in an Italian population of MS patients and demonstrate its reliability and construct validity.

methodsWe included patients with diagnosis of MS, age between 18 and 70 years with ability to participate in a 90-min interview. Each patient completed the Italian version of FSIQ-RMS and Fatigue Severity Scale (FSS) at the same time. Construct validity was explored by the exploratory factor analysis; reliability was assessed with Cronbach's alpha; and test-retest stability was examined through intraclass correlation coefficient (ICC). Concurrent validity was calculated using Pearson's correlation.

resultsWe enrolled 171 patients (126 female and 45 male), 83% with relapsing MS (RMS), and 17% with secondary progressive MS (SPMS). Italian FSIQ-RMS showed a Cronbach's alpha of 0.92; ICC was 0.96. Pearson's correlation coefficient between FSIQ-RMS and FSS total score was statistically significant (p < 0.01); FSIQ-RMS inversely correlated also with BMI and positively with EDSS.

conclusionThe Italian version of FSIQ-RMS has excellent psychometric properties and can be used in research and clinical setting to evaluate physical, cognitive, and social fatigue in both RMS and SPMS.

Indexed as

Multiple SclerosisAdolescentAdultAgedFatigueFemaleHumansMaleMiddle AgedPsychometricsReproducibility of ResultsSurveys and QuestionnairesYoung AdultFatigueFSIQ-RMSFSSItalian validationMultiple sclerosis

Identifiers

PMID35451663

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.