Evidence map›Paper›PMID 35453530›Full record

ArticleBiomedicines2022

The Effectiveness of Isoplumbagin and Plumbagin in Regulating Amplitude, Gating Kinetics, and Voltage-Dependent Hysteresis of

Linyi Chen, Hsin-Yen Cho, Tzu-Hsien Chuang, Ting-Ling Ke, Sheng-Nan Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Modulation ofInternational journal of molecular sciences · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Evidence for Dual Activation ofInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Linyi ChenInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Hsin-Yen ChoDepartment of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.
Tzu-Hsien ChuangDepartment of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.
Ting-Ling KeInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Sheng-Nan WuDepartment of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.ORCID 0000-0002-5208-3253
National Cheng Kung University · TWNational Tsing Hua University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 108-2320-B-007 -005 -MY3Ministry of Science and Technology, Taiwan MOST-110-2320-B-006-028National Health Research Institutes, Taiwan NHRI-EX111-10813NI
6 · The paper itself

Abstract

Isoplumbagin (isoPLB, 5-hydroxy-3-methyl-1,4-naphthoquinone), a naturally occurring quinone, has been observed to exercise anti-inflammatory, antimicrobial, and antineoplastic activities. Notably, whether and how isoPLB, plumbagin (PLB), or other related compounds impact transmembrane ionic currents is not entirely clear. In this study, during GH

Indexed as

current kineticsdelayed-rectifier K+ currenterg-mediated K+ currentisoplumbagin (5-hydroxy-3-methyl-1,4-naphthoquinone)Leydig cellpituitary cellplumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone)voltage-dependent hysteresisvoltage-gated Na+ current

Identifiers

PMID35453530
PMCPMC9029050
OpenAlexW4221088018

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.