Evidence map›Paper›PMID 35453981›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Radiomics Analysis of Brain [

Pierpaolo Alongi, Riccardo Laudicella, Francesco Panasiti, Alessandro Stefano, Albert Comelli, Paolo Giaccone, Annachiara Arnone, Fabio Minutoli, Natale Quartuccio, Chiara Cupidi and 5 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Predictive value ofFrontiers in oncology · 2026
    Article
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  16. Beyond Macrostructure: Is There a Role for Radiomics Analysis in Neuroimaging ?Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pierpaolo AlongiNuclear Medicine Unit, ARNAS Ospedali Civico, Di Cristina e Benfratelli, 90133 Palermo, Italy.ORCID 0000-0002-8397-1640
Riccardo LaudicellaNuclear Medicine Unit, Fondazione Istituto G. Giglio, Contrada Pietrapollastra Pisciotto, 90015 Cefalù, Italy.ORCID 0000-0002-2842-0301
Francesco PanasitiNuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging Nuclear Medicine Unit, University of Messina, 98122 Messina, Italy.
Alessandro StefanoInstitute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 90015 Cefalù, Italy.ORCID 0000-0002-7189-1731
Albert ComelliRi.Med Foundation, Via Bandiera 11, 90133 Palermo, Italy.ORCID 0000-0002-9290-6103
Paolo GiacconeRi.Med Foundation, Via Bandiera 11, 90133 Palermo, Italy.ORCID 0000-0001-9239-7786
Annachiara ArnoneNuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.ORCID 0000-0003-4182-9264
Fabio MinutoliNuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging Nuclear Medicine Unit, University of Messina, 98122 Messina, Italy.ORCID 0000-0002-5768-9764
Natale QuartuccioNuclear Medicine Unit, ARNAS Ospedali Civico, Di Cristina e Benfratelli, 90133 Palermo, Italy.ORCID 0000-0001-9845-1384
Chiara CupidiNeurology Unit, Fondazione Istituto G. Giglio, 90015 Cefalù, Italy.
Gaspare ArnoneNuclear Medicine Unit, ARNAS Ospedali Civico, Di Cristina e Benfratelli, 90133 Palermo, Italy.
Tommaso PiccoliUnit of Neurology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy.
Luigi Maria Edoardo GrimaldiNeurology Unit, Fondazione Istituto G. Giglio, 90015 Cefalù, Italy.
Sergio BaldariNuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging Nuclear Medicine Unit, University of Messina, 98122 Messina, Italy.
Giorgio RussoInstitute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 90015 Cefalù, Italy.ORCID 0000-0003-1493-1087

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly in-vivo diagnosis of Alzheimer's disease (AD) is crucial for accurate management of patients, in particular, to select subjects with mild cognitive impairment (MCI) that may evolve into AD, and to define other types of MCI non-AD patients. The application of artificial intelligence to functional brain [

methodsFrom July 2016 to September 2017, 43 patients underwent PET/CT scans with FDG and Florbetaben brain PET/CT and at least 24 months of clinical/instrumental follow-up. Patients were retrospectively evaluated by a multidisciplinary team (MDT = Neurologist, Psychologist, Radiologist, Nuclear Medicine Physician, Laboratory Clinic) at the G. Giglio Institute in Cefalù, Italy. Starting from the cerebral segmentations applied by SPM on the main cortical macro-areas of each patient, Pyradiomics was used for the feature extraction process; subsequently, an innovative descriptive-inferential mixed sequential approach and a machine learning algorithm (i.e., discriminant analysis) were used to obtain the best diagnostic performance in prediction of amyloid deposition and the final diagnosis of AD.

resultsA total of 11 radiomics features significantly predictive of cortical beta-amyloid deposition (

conclusionsThe results obtained in this preliminary study support advanced segmentation of cortical areas typically involved in early AD on FDG PET/CT brain images, and radiomics analysis for the identification of specific high-order features to predict Amyloid deposition and final diagnosis of AD.

Indexed as

Alzheimer’s diseasemachine learningPET/CTradiomics

Identifiers

PMID35453981
PMCPMC9030037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.