Evidence map›Paper›PMID 35454849›Full record

ArticleCancers2022

Investigating the Prognostic Relevance of Tumor Immune Microenvironment and Immune Gene Assembly in Breast Carcinoma Subtypes.

Beáta Szeitz, Orsolya Pipek, Janina Kulka, Csilla Szundi, Orsolya Rusz, Tímea Tőkés, Attila Marcell Szász, Kristóf Attila Kovács, Adrián Pesti, Taya Beri Ben Arie and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Beáta SzeitzDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.ORCID 0000-0001-6414-0537
Orsolya PipekDepartment of Physics of Complex Systems, Institute of Physics, Eötvös Loránd University, 1117 Budapest, Hungary.
Janina KulkaDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Csilla SzundiDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Orsolya RuszDepartment of Pathology, Forensic and Insurance Medicine, SE NAP, Brain Metastasis Research Group, Semmelweis University, 1091 Budapest, Hungary.
Tímea TőkésDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Attila Marcell SzászDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.ORCID 0000-0003-2739-4196
Kristóf Attila KovácsDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Adrián PestiDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.ORCID 0000-0001-6706-6221
Taya Beri Ben ArieDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Ambrus GángóMTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.
Zsolt FülöpDepartment of Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Targu Mures, Romania.ORCID 0000-0002-0854-5617
Emőke DrágusDepartment of Urology, Clinical County Hospital, 540167 Targu Mures, Romania.
Stefan A Vári-KakasFaculty of Electrical Engineering and Information Technology, University of Oradea, Str. Universitatii nr. 1, 410087 Oradea, Romania.
Anna Mária TőkésDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Semmelweis University · HUEötvös Loránd University · HUUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · ROUniversity of Oradea · RO

Funding

Hungarian National Research, Development and Innovation Office KNN121510Hungarian National Research, Development and Innovation Office NVKP_16-1-2016-0004
6 · The paper itself

Abstract

We hypothesized that different BC subtypes are characterized by spatially distinct tumor immune microenvironment (TIME) and that immune gene assembly of metastatic (Met) and non-metastatic (Ctrl) BCs vary across subtypes. Peritumoral, stromal and intratumoral TIL was assessed on 309 BC cases. Hot, cold and immune-excluded groups were defined, and the prognostic role of this classification was assessed. CD4

Indexed as

breast carcinoma subtypesCD4+ T cellsCD8+ T cellsimmune-related geneNanoStringTIL

Identifiers

PMID35454849
PMCPMC9031175
OpenAlexW4223616468

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.