Evidence map›Paper›PMID 35454972›Full record

ReviewLife (Basel, Switzerland)2022

Cancer-Derived Extracellular Vesicles: Their Role in Sarcoma.

Anita Adib, Ruhi Sahu, Shivangi Mohta, Raphael Etomar Pollock, Lucia Casadei

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anita AdibThe James Cancer Hospital Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Ruhi SahuThe James Cancer Hospital Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Shivangi MohtaThe James Cancer Hospital Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Raphael Etomar PollockDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-0443-1583
Lucia CasadeiThe James Cancer Hospital Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
NIH HHS CA016058United States Department of Defense CA210874
6 · The paper itself

Abstract

Soft tissue sarcomas (STS) are rare malignancies with limited responses to anticancer therapy. Extracellular vesicles (EVs) are a heterogeneous group of bi-lipid layer sacs secreted by cells into extracellular space. Investigations of tumor-derived EVs have revealed their functional capabilities, including cell-to-cell communication and their impact on tumorigenesis, progression, and metastasis; however information on the roles of EVs in sarcoma is currently limited. In this review we investigate the role of various EV cargos in sarcoma and the mechanisms by which those cargos can affect the recipient cell phenotype and the aggressivity of the tumor itself. The study of EVs in sarcoma may help establish novel therapeutic approaches that target specific sarcoma subtypes or biologies, thereby improving sarcoma therapeutics in the future.

Indexed as

cancercargoEwing’s sarcomaextracellular vesiclesKaposi’s sarcomaliposarcomaosteosarcomarhabdomyosarcomasarcomatumorigenesis

Identifiers

PMID35454972
PMCPMC9029613
OpenAlexW4220816778

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.