Evidence map›Paper›PMID 35455357›Full record

ReviewVaccines2022

COVID-19 Vaccines: Current and Future Perspectives.

Luca Soraci, Fabrizia Lattanzio, Giulia Soraci, Maria Elsa Gambuzza, Claudio Pulvirenti, Annalisa Cozza, Andrea Corsonello, Filippo Luciani, Giovanni Rezza

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Characteristics of Oral Adverse Effects following COVID-19 Vaccination and Similarities with Oral Symptoms in COVID-19 Patients: Taste and Saliva Secretory Disorders.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Review
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  9. Review
  10. Computational Drug Design Strategies for Fighting the COVID-19 Pandemic.Advances in experimental medicine and biology · 2024
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Luca SoraciUnit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), 87100 Cosenza, Italy.ORCID 0000-0002-0171-3358
Fabrizia LattanzioScientific Direction, Italian National Research Center on Aging (IRCCS INRCA), 60121 Ancona, Italy.
Giulia SoraciDepartment of Obstetrics and Gynecology, University of Ferrara, 44121 Ferrara, Italy.
Maria Elsa GambuzzaTerritorial Office of Messina, Italian Ministry of Health, 98122 Messina, Italy.
Claudio PulvirentiUSMAF Sicily, Italian Ministry of Health, 90133 Palermo, Italy.
Annalisa CozzaLaboratory of Pharmacoepidemiology and Biostatistics, Italian National Research Center on Aging (IRCCS INRCA), 87100 Cosenza, Italy.
Andrea CorsonelloUnit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), 87100 Cosenza, Italy.ORCID 0000-0002-7276-3256
Filippo LucianiInfectious Diseases Unit of Annunziata Hospital, 87100 Cosenza, Italy.
Giovanni RezzaHealth Prevention Directorate, Italian Ministry of Health, 00144 Rome, Italy.
Istituto Nazionale di Riposo e Cura per Anziani · ITMinistero della Salute · ITOspedale Annunziata di Cosenza · ITUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently available vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are highly effective but not able to keep the coronavirus disease 2019 (COVID-19) pandemic completely under control. Alternative R&D strategies are required to induce a long-lasting immunological response and to reduce adverse events as well as to favor rapid development and large-scale production. Several technological platforms have been used to develop COVID-19 vaccines, including inactivated viruses, recombinant proteins, DNA- and RNA-based vaccines, virus-vectored vaccines, and virus-like particles. In general, mRNA vaccines, protein-based vaccines, and vectored vaccines have shown a high level of protection against COVID-19. However, the mutation-prone nature of the spike (S) protein affects long-lasting vaccine protection and its effectiveness, and vaccinated people can become infected with new variants, also showing high virus levels. In addition, adverse effects may occur, some of them related to the interaction of the S protein with the angiotensin-converting enzyme 2 (ACE-2). Thus, there are some concerns that need to be addressed and challenges regarding logistic problems, such as strict storage at low temperatures for some vaccines. In this review, we discuss the limits of vaccines developed against COVID-19 and possible innovative approaches.

Indexed as

COVID-19innovative approachespandemicrecombinant vaccinesS protein

Identifiers

PMID35455357
PMCPMC9025326
OpenAlexW4223945244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.