ArticleCells2022
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.
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Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Folding-mediated secretion of pure bispecific antibodies.Nature biotechnology · 2026Article
- Prolyl-3-hydroxylase 1 is a central regulator of collagen post-translational modifications and the collagen biosynthetic network.The Journal of biological chemistry · 2026Article
- Monocyte-plasma cell communication characterizes treatment-associated peripheral immune remodeling in Guillain-Barré syndrome.Frontiers in immunology · 2026Article
- A reconstruction of the mammalian secretory pathway identifies mechanisms regulating antibody production.Cell systems · 2025Article
- The Effects of Clazakizumab on Peripheral Blood and Kidney Transcriptomes in Patients With Late Antibody-Mediated Rejection.Kidney international reports · 2025Article
- Long-read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neurons.Open biology · 2025Article
- Distinct mural cells and fibroblasts promote pathogenic plasma cell accumulation in idiopathic pulmonary fibrosis.The European respiratory journal · 2025Article
- Immune mechanisms and novel therapies for idiopathic pulmonary fibrosis.Pharmaceutical science advances · 2024Review
- The prolyl isomerase FKBP11 is a secretory translocon accessory factor.Molecular biology of the cell · 2024Article
- Article
- Precision medicine advances in idiopathic pulmonary fibrosis.EBioMedicine · 2023Review
- Machine learning-based prediction of candidate gene biomarkers correlated with immune infiltration in patients with idiopathic pulmonary fibrosis.Frontiers in medicine · 2023Article
- Article
- Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
24 authors at 5 institutions in 2 countries.
Stefan PreisendörferInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Yoshihiro IshikawaDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0003-2013-0518
Elisabeth HennenInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Stephan WinklmeierInstitute of Clinical Neuroimmunology, Biomedical Center and LMU Klinikum, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.ORCID 0000-0001-8675-0387
Jonas C SchuppPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-7714-8076
Larissa KnüppelInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.ORCID 0000-0002-6338-692X
Isis E FernandezInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Leonhard BinzenhöferInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Andrew FlatleyMonoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz-Zentrum München, 85764 Neuherberg, Germany.ORCID 0000-0001-7822-132X
Brenda M Juan-GuardelaPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Clemens RuppertDepartment of Internal Medicine, Medizinische Klinik II, Member of the German Center of Lung Research (DZL), 35392 Giessen, Germany.ORCID 0000-0002-0938-2469
Andreas GuentherDepartment of Internal Medicine, Medizinische Klinik II, Member of the German Center of Lung Research (DZL), 35392 Giessen, Germany.
Marion FrankenbergerInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Rudolf A HatzThoraxchirurgisches Zentrum, Klinik für Allgemeine-, Viszeral-, Transplantations-, Gefäß- und Thoraxchirurgie, LMU Klinikum, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
Nikolaus KneidingerDepartment of Medicine V, LMU Klinikum, Ludwig-Maximilians-Universität München, Member of the German Center of Lung Research (DZL), 81377 Munich, Germany.ORCID 0000-0001-7583-0453
Jürgen BehrDepartment of Medicine V, LMU Klinikum, Ludwig-Maximilians-Universität München, Member of the German Center of Lung Research (DZL), 81377 Munich, Germany.
Regina FeederleMonoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz-Zentrum München, 85764 Neuherberg, Germany.ORCID 0000-0002-3981-367X
Aloys SchepersMonoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz-Zentrum München, 85764 Neuherberg, Germany.
Anne HilgendorffInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Naftali KaminskiPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Edgar MeinlInstitute of Clinical Neuroimmunology, Biomedical Center and LMU Klinikum, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.ORCID 0000-0002-2570-6785
Hans Peter BächingerDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239, USA.
Oliver EickelbergInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Claudia A Staab-WeijnitzInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.ORCID 0000-0002-1211-7834
Helmholtz Zentrum München · DELMU Klinikum · DEYale University · USGerman Center for Lung Research · DEOregon Health & Science University · US
Funding
TriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0MLung Genomics Research ConsortiumRC2HL101715 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GERACI, MARK W, KAMINSKI, NAFTALI · 2009 to 2010
$11.4MExtracellular matrix composition and crosslinking patterns determine resident cell function in lung fibrosisR01HL146519 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EICKELBERG, OLIVER · 2020 to 2023
$2.5MGene networks beyond organ boundaries; heart, lung and pulmonary vascular diseaseU01HL108642 · NHLBI · YALE UNIVERSITY · PI AHMAD, FERHAAN, BENOS, PANAGIOTIS V · 2011 to 2014
$2.2MNHLBI NIH HHS R01 HL146519NHLBI NIH HHS RC2 HL101715NHLBI NIH HHS U01 HL108642NIA NIH HHS U54 AG075931
Abstract
Antibodies are central effectors of the adaptive immune response, widespread used therapeutics, but also potentially disease-causing biomolecules. Antibody folding catalysts in the plasma cell are incompletely defined. Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease with increasingly recognized autoimmune features. We found elevated expression of FK506-binding protein 11 (
Indexed as
Idiopathic Pulmonary FibrosisTacrolimus Binding ProteinsHumansImmunoglobulin GPeptidylprolyl IsomerasePlasma CellsFKBP11 protein, humanImmunoglobulin GPeptidylprolyl IsomeraseTacrolimus Binding Proteinsantibody foldingER stressFK506-binding proteinimmunophilininterstitial lung diseaselung fibrosispeptidyl-prolyl isomerasetacrolimus
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What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.