Evidence map›Paper›PMID 35456320›Full record

ArticleJournal of clinical medicine2022

Combination of HLA-DQ2/-DQ8 Haplotypes and a Single MSH5 Gene Variant in a Polish Population of Patients with Type 1 Diabetes as a First Line Screening for Celiac Disease?

Marta Wysocka-Mincewicz, Artur Groszek, Filip Ambrozkiewicz, Agnieszka Paziewska, Michalina Dąbrowska, Anna Rybak, Ewa Konopka, Agnieszka Ochocińska, Natalia Żeber-Lubecka, Jakub Karczmarski and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Marta Wysocka-MincewiczDepartment of Endocrinology and Diabetology of the Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.ORCID 0000-0001-8213-9759
Artur GroszekDepartment of Endocrinology and Diabetology of the Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.
Filip AmbrozkiewiczDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.ORCID 0000-0001-6850-780X
Agnieszka PaziewskaDepartment of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
Michalina DąbrowskaDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.
Anna RybakDepartment of Gastroenterology, Great Ormond Street Hospital NHS Trust, Great Ormond Street, London WC1N 3JH, UK.ORCID 0000-0002-8233-5490
Ewa KonopkaDepartment of Pathomorphology of the Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.
Agnieszka OchocińskaDepartment of Biochemistry, Radioimmunology and Experimental Medicine of the Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.ORCID 0000-0002-6997-6197
Natalia Żeber-LubeckaDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.
Jakub KarczmarskiDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.
Joanna B BierłaDepartment of Pathomorphology of the Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.ORCID 0000-0002-5772-5091
Ilona TrojanowskaDepartment of Pathomorphology of the Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.
Agnieszka RogowskaDepartment of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
Jerzy OstrowskiDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.
Bożena CukrowskaDepartment of Pathomorphology of the Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.ORCID 0000-0001-6887-0094
Children's Memorial Health Institute · PLPostgraduate School of Molecular Medicine · PLCharles University · CZGreat Ormond Street Hospital · GBThe Maria Sklodowska-Curie National Research Institute of Oncology · PLUniversity of Siedlce · PL

Funding

The Children's Memorial Health Institute M32/18The Children's Memorial Health Institute S156/2017The Children's Memorial Health Institute S186/2020
6 · The paper itself

Abstract

Patients with type 1 diabetes (T1D) are at increased risk for developing celiac disease (CD). The aim of the study was to assess the usefulness of celiac-specific human leukocyte antigen (HLA) haplotype and the rs3130484 variant of MSH5 gene, a previously described non-HLA variant associated with CD in the Polish population as a first-line screening for CD in T1D pediatric patients. Serological CD screening performed in the T1D group (

Indexed as

celiac diseasegenetic screeningHLA-DQ2 haplotypeHLA-DQ8 haplotypeMSH5 genetype 1 diabetes

Identifiers

PMID35456320
PMCPMC9025645
OpenAlexW4223967409

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.