Evidence map›Paper›PMID 35456342›Full record

ArticleJournal of clinical medicine2022

Corneal Confocal Microscopy Identifies People with Type 1 Diabetes with More Rapid Corneal Nerve Fibre Loss and Progression of Neuropathy.

Uazman Alam, Georgios Ponirakis, Omar Asghar, Ioannis N Petropoulos, Shazli Azmi, Maria Jeziorska, Andrew Marshall, Andrew J M Boulton, Nathan Efron, Rayaz A Malik

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In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Uazman AlamDivision of Diabetes, Endocrinology and Gastroenterology, Institute of Human Development, University of Manchester, Manchester M13 9PL, UK.
Georgios PonirakisDepartment of Medicine, Weill Cornell Medicine-Qatar, Doha 24144, Qatar.
Omar AsgharDivision of Diabetes, Endocrinology and Gastroenterology, Institute of Human Development, University of Manchester, Manchester M13 9PL, UK.
Ioannis N PetropoulosDepartment of Medicine, Weill Cornell Medicine-Qatar, Doha 24144, Qatar.
Shazli AzmiDivision of Diabetes, Endocrinology and Gastroenterology, Institute of Human Development, University of Manchester, Manchester M13 9PL, UK.
Maria JeziorskaInstitute of Cardiovascular Science, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-3492-0177
Andrew MarshallDivision of Diabetes, Endocrinology and Gastroenterology, Institute of Human Development, University of Manchester, Manchester M13 9PL, UK.
Andrew J M BoultonDivision of Diabetes, Endocrinology and Gastroenterology, Institute of Human Development, University of Manchester, Manchester M13 9PL, UK.
Nathan EfronInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane City, QLD 4000, Australia.ORCID 0000-0002-7037-779X
Rayaz A MalikDepartment of Medicine, Weill Cornell Medicine-Qatar, Doha 24144, Qatar.ORCID 0000-0002-7188-8903

Funding

Breakthrough T1D 8-2008-362Wellcome Trust
6 · The paper itself

Abstract

There is a need to accurately identify patients with diabetes at higher risk of developing and progressing diabetic peripheral neuropathy (DPN). Fifty subjects with Type 1 Diabetes Mellitus (T1DM) and sixteen age matched healthy controls underwent detailed neuropathy assessments including symptoms, signs, quantitative sensory testing (QST), nerve conduction studies (NCS), intra epidermal nerve fiber density (IENFD) and corneal confocal microscopy (CCM) at baseline and after 2 years of follow-up. Overall, people with type 1 diabetes mellitus showed no significant change in HbA1c, blood pressure, lipids or neuropathic symptoms, signs, QST, neurophysiology, IENFD and CCM over 2 years. However, a sub-group (

Indexed as

corneal confocal microscopy (CCM)diabetic peripheral neuropathy (DPN)Intra-epidermal nerve fiber density (IENFD)nerve conduction studies (NCS)

Identifiers

PMID35456342
PMCPMC9030140

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.