Evidence mapPaperPMID 35456412Full record

ArticleGenes2022

Polymorphisms in Human

María Luisa Reigada-Rivera, Catalina Sanz Lozano, Esther Moreno Rodilla, Asunción García-Sánchez, Virginia García-Solaesa, Félix Lorente Toledano, Ignacio Dávila González, María Isidoro-García

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

María Luisa Reigada-RiveraDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.
Catalina Sanz LozanoBiomedical Research Institute of Salamanca IBSAL, 37007 Salamanca, Spain.
Esther Moreno RodillaBiomedical Research Institute of Salamanca IBSAL, 37007 Salamanca, Spain.
Asunción García-SánchezBiomedical Research Institute of Salamanca IBSAL, 37007 Salamanca, Spain.ORCID 0000-0002-9655-4918
Virginia García-SolaesaDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-5996-1429
Félix Lorente ToledanoBiomedical Research Institute of Salamanca IBSAL, 37007 Salamanca, Spain.
Ignacio Dávila GonzálezBiomedical Research Institute of Salamanca IBSAL, 37007 Salamanca, Spain.ORCID 0000-0001-8485-5513
María Isidoro-GarcíaDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.
Universidad de Salamanca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of genetics in non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (NERD) is unclear, with different candidates involved, such as

methodsWe included 195 patients (85 with NERD and 110 with respiratory disease who tolerate NSAIDs) and 156 controls (non-atopic individuals without a history of asthma, nasal polyposis (NP), or NSAID hypersensitivity). Genotyping was performed by sequence-specific primer polymerase chain reaction (PCR-SSP). Amplicons were analyzed by horizontal gel electrophoresis in 2% agarose.

resultsSignificant differences in allele and genotype frequency distributions were found in

conclusionsRetrospectively recorded, we found strong associations of NERD with polymorphisms in

Indexed as

Anti-Inflammatory Agents, Non-SteroidalHypersensitivityInterleukin-10HumansInterleukin-4Polymorphism, Single NucleotideRetrospective StudiesTumor Necrosis Factor-alphaAnti-Inflammatory Agents, Non-SteroidalIL10 protein, humanInterleukin-10Interleukin-4TNF protein, humanTumor Necrosis Factor-alphaasthmanasal polyposisNERDNSAID hypersensitivitypolymorphism

Identifiers

PMID35456412
PMCPMC9031626
OpenAlexW4220759341

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.