Evidence map›Paper›PMID 35457021›Full record

ArticleInternational journal of molecular sciences2022

Fluorine-Containing Drug Administration in Rats Results in Fluorination of Selected Proteins in Liver and Brain Tissue.

Andrzej Gawor, Zdzislaw Gajewski, Leszek Paczek, Bozena Czarkowska-Paczek, Anna Konopka, Grzegorz Wryk, Ewa Bulska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Andrzej GaworBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland.ORCID 0000-0001-9578-4968
Zdzislaw GajewskiCenter for Translational Medicine, Warsaw University of Life Science, Nowoursynowska 100, 02-797 Warsaw, Poland.ORCID 0000-0001-8779-5050
Leszek PaczekDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland.ORCID 0000-0003-0160-3009
Bozena Czarkowska-PaczekDepartment of Clinical Nursing, Medical University of Warsaw, Ciolka Street 27, 01-445 Warsaw, Poland.ORCID 0000-0002-1023-3057
Anna KonopkaBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
Grzegorz WrykBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
Ewa BulskaBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
University of Warsaw · PLMedical University of Warsaw · PLWarsaw University of Life Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In many pharmaceuticals, a hydrogen atom or hydroxyl group is replaced by a fluorine to increase bioavailability and biostability. The fate of fluorine released from fluorine-containing drugs is not well investigated. The aim of this study was to examine possible fluorination of proteins in rat liver and brain after administration of the fluorinated drug cinacalcet. We assigned 18 Wistar rats to a control group (

Indexed as

FluorineHalogenationAnimalsBrainCinacalcetFluoridesLiverPharmaceutical PreparationsRatsRats, WistarSpectrinTandem Mass SpectrometryCinacalcetFluoridesFluorinePharmaceutical PreparationsSpectrindrug biotransformationfluorinated drugfluorineprotein fluorination

Identifiers

PMID35457021
PMCPMC9028303
OpenAlexW4223415773

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.