Evidence map›Paper›PMID 35457119›Full record

ArticleInternational journal of molecular sciences2022

Frequency-Dependent Properties of the Hyperpolarization-Activated Cation Current, I

Wei Hu, Robert B Clark, Wayne R Giles, Colleen Kondo, Henggui Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. New Insights into Cardiac Ion Channel Regulation 2.0.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Wei HuBiological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-4637-8995
Robert B ClarkDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Wayne R GilesDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Colleen KondoDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Henggui ZhangBiological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, UK.
University of Calgary · CAUniversity of Manchester · GB

Funding

British Heart Foundation FS/PhD/20/29053
6 · The paper itself

Abstract

A number of distinct electrophysiological mechanisms that modulate the myogenic spontaneous pacemaker activity in the sinoatrial node (SAN) of the mammalian heart have been investigated extensively. There is agreement that several (3 or 4) different transmembrane ionic current changes (referred to as the voltage clock) are involved; and that the resulting net current interacts with direct and indirect effects of changes in intracellular Ca

Indexed as

Myocytes, CardiacSinoatrial NodeAction PotentialsAnimalsCationsIon ChannelsIsoproterenolMammalsMiceCationsIon ChannelsIsoproterenolhyperpolarization-activated currentIfmathematical modelingmouse heartpacemaker depolarizationresidual activationSANsino-atrial nodespontaneous pacemaker activityβ adrenergic stimulation

Identifiers

PMID35457119
PMCPMC9024942
OpenAlexW4223967740

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.