Evidence map›Paper›PMID 35457283›Full record

ArticleInternational journal of molecular sciences2022

Functional Characterization of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G).

Roua Hassoun, Constanze Erdmann, Sebastian Schmitt, Setsuko Fujita-Becker, Andreas Mügge, Rasmus R Schröder, Matthias Geyer, Mina Borbor, Kornelia Jaquet, Nazha Hamdani and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Identification ofDiagnostics (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Roua HassounInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Medical Faculty, Ruhr University Bochum, D-44791 Bochum, Germany.
Constanze ErdmannDepartment of Anatomy and Molecular Embryology, Medical Faculty, Ruhr-University Bochum, D-44780 Bochum, Germany.
Sebastian SchmittInstitute of Structural Biology, University of Bonn, D-53127 Bonn, Germany.
Setsuko Fujita-BeckerCryoelectron Microscopy, BioQuant, Medical Faculty, University of Heidelberg, D-69120 Heidelberg, Germany.
Andreas MüggeInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Medical Faculty, Ruhr University Bochum, D-44791 Bochum, Germany.ORCID 0000-0001-9548-6995
Rasmus R SchröderCryoelectron Microscopy, BioQuant, Medical Faculty, University of Heidelberg, D-69120 Heidelberg, Germany.
Matthias GeyerInstitute of Structural Biology, University of Bonn, D-53127 Bonn, Germany.ORCID 0000-0002-7718-5002
Mina BorborDepartment of Neurology, University Hospital Essen, D-45147 Essen, Germany.
Kornelia JaquetInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Medical Faculty, Ruhr University Bochum, D-44791 Bochum, Germany.
Nazha HamdaniInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Medical Faculty, Ruhr University Bochum, D-44791 Bochum, Germany.
Hans Georg MannherzInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Medical Faculty, Ruhr University Bochum, D-44791 Bochum, Germany.
St. Josef-Hospital · DEHeidelberg University · DERuhr University Bochum · DEUniversity of Bonn · DEEssen University Hospital · DE

Funding

Deutsche Forschungsgemeinschaft Ma 807/19-1
6 · The paper itself

Abstract

Human wild type (wt) cardiac α-actin and its mutants p.A295S or p.R312H and p.E361G correlated with hypertrophic or dilated cardiomyopathy, respectively, were expressed by using the

Indexed as

Cardiomyopathy, DilatedCardiomyopathy, HypertrophicActin CytoskeletonActinsAnimalsCalciumCattleHumansHypertrophyMutationMyosinsTropomyosinActinsCalciumMyosinsTropomyosincalcium sensitivitycardiac actincardiomyopathieslevosimendanmyosin binding protein Cmyosin subfragment 1

Identifiers

PMID35457283
PMCPMC9024677
OpenAlexW4224300339

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.