Evidence mapPaperPMID 35458148Full record

Observational studyNutrients2022

Vitamin D Deficiency in Women with Breast Cancer: A Correlation with Osteoporosis? A Machine Learning Approach with Multiple Factor Analysis.

Alessandro de Sire, Luca Gallelli, Nicola Marotta, Lorenzo Lippi, Nicola Fusco, Dario Calafiore, Erika Cione, Lucia Muraca, Antonio Maconi, Giovambattista De Sarro and 2 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Multidimensional evaluation of clinical and functional impairment in a large population of patients with Charcot-Marie-Tooth.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Serum Vitamin DNutrients · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Understanding the role ofFrontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Alessandro de SirePhysical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy.ORCID 0000-0002-5541-8346
Luca GallelliOperative Unit of Clinical Pharmacology, Mater Domini University Hospital, Department of Health Science, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy.ORCID 0000-0003-0858-7902
Nicola MarottaPhysical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy.ORCID 0000-0002-5568-7909
Lorenzo LippiTranslational Medicine, Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0001-9035-1485
Nicola FuscoDepartment of Oncology and Hemato-Oncology, University of Milan, 20126 Milan, Italy.ORCID 0000-0002-9101-9131
Dario CalafiorePhysical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma, 46100 Mantova, Italy.ORCID 0000-0001-9221-2497
Erika CioneDepartment of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-0562-0597
Lucia MuracaDepartment of General Medicine, ASP 7, 88100 Catanzaro, Italy.
Antonio MaconiTranslational Medicine, Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Giovambattista De SarroOperative Unit of Clinical Pharmacology, Mater Domini University Hospital, Department of Health Science, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy.ORCID 0000-0002-7629-6579
Antonio AmmendoliaPhysical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy.ORCID 0000-0002-2828-2455
Marco InvernizziTranslational Medicine, Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0001-5141-0681
Magna Graecia University · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITAzienda Ospedaliera Carlo Poma · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITUniversity of Calabria · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is the most frequent malignant tumor in women in Europe and North America, and the use of aromatase inhibitors (AIs) is recommended in women affected by estrogen receptor-positive BCs. AIs, by inhibiting the enzyme that converts androgens into estrogen, cause a decrement in bone mineral density (BMD), with a consequent increased risk of fragility fractures. This study aimed to evaluate the role of vitamin D3 deficiency in women with breast cancer and its correlation with osteoporosis and BMD modifications. This observational cross-sectional study collected the following data regarding bone health: osteoporosis and osteopenia diagnosis, lumbar spine (LS) and femoral neck bone mineral density (BMD), serum levels of 25-hydroxyvitamin D3 (25(OH)D3), calcium and parathyroid hormone. The study included 54 women with BC, mean age 67.3 ± 8.16 years. Given a significantly low correlation with the LS BMD value (r

Indexed as

Breast NeoplasmsOsteoporosisVitamin D DeficiencyAgedBone DensityCalcifediolFactor Analysis, StatisticalFemaleHumansMachine LearningMiddle AgedVitamin DCalcifediolVitamin Dbone mineral densitybreast cancercluster analysismachine learningmultiple factor analysisosteoporosisvitamin D

Identifiers

PMID35458148
PMCPMC9031622
OpenAlexW4223507030

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.