Evidence mapPaperPMID 35458199Full record

Trial reportNutrients2022

Probiotics-Supplemented Low-Protein Diet for Microbiota Modulation in Patients with Advanced Chronic Kidney Disease (ProLowCKD): Results from a Placebo-Controlled Randomized Trial.

Andreana De Mauri, Deborah Carrera, Marco Bagnati, Roberta Rolla, Matteo Vidali, Doriana Chiarinotti, Marco Pane, Angela Amoruso, Mario Del Piano

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Review
  9. Gut-kidney axis: Dysbiosis and renal disease.World journal of nephrology · 2026
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Dietary Intake and Gut Microbiome in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andreana De MauriNephrology and Dialysis Unit, Maggiore della Carità University Hospital, 28100 Novara, Italy.ORCID 0000-0002-3266-195X
Deborah CarreraDietetic and Clinical Nutrition, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Marco BagnatiClinical Chemistry Laboratory, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Roberta RollaClinical Chemistry Laboratory, Maggiore della Carità University Hospital, 28100 Novara, Italy.ORCID 0000-0003-0805-8285
Matteo VidaliClinical Chemistry Unit, Fondazione IRCCS Ca' Granda Maggiore Policlinico Hospital, 20122 Milano, Italy.ORCID 0000-0001-9991-7502
Doriana ChiarinottiNephrology and Dialysis Unit, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Marco PaneResearch & Development, Probiotical Research Srl, 28100 Novara, Italy.
Angela AmorusoResearch & Development, Probiotical Research Srl, 28100 Novara, Italy.
Mario Del PianoPast head of Clinical Research, Probiotical SpA, 28100 Novara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The probiotics-supplemented low-protein diet in chronic kidney disease (ProLowCKD) was a single-centre, double-blind, placebo-controlled, randomised trial that was conducted to investigate whether the association between a low protein diet (LPD) and a new formulation of probiotics (

Indexed as

Gastrointestinal MicrobiomeMicrobiotaProbioticsRenal Insufficiency, ChronicToxins, BiologicalCholesterol, LDLDiet, Protein-RestrictedDouble-Blind MethodFemaleHumansMaleCholesterol, LDLToxins, Biologicalchronic kidney diseaseecologic therapygreen nephrologygut microbiotalow protein dietmicrobial uremic toxinsprobiotics

Identifiers

PMID35458199
PMCPMC9025298

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.