Evidence map›Paper›PMID 35458307›Full record

ReviewPolymers2022

Design and Fabrication of Polymeric Hydrogel Carrier for Nerve Repair.

Xiaoyu Ma, Mengjie Wang, Yuanyuan Ran, Yusi Wu, Jin Wang, Fuhai Gao, Zongjian Liu, Jianing Xi, Lin Ye, Zengguo Feng

Abstract readReview
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoyu MaSchool of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
Mengjie WangSchool of Beijing Rehabilitation Medicine, Capital Medical University, Beijing 100044, China.
Yuanyuan RanDepartment of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical School, Beijing 100044, China.
Yusi WuKey Laboratory of Multifunctional Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
Jin WangKey Laboratory of Multifunctional Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.ORCID 0000-0003-1573-574X
Fuhai GaoDepartment of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical School, Beijing 100044, China.
Zongjian LiuDepartment of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical School, Beijing 100044, China.
Jianing XiDepartment of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical School, Beijing 100044, China.
Lin YeSchool of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
Zengguo FengSchool of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.

Funding

Beijing Municipal Natural Science Foundation 7222102National Natural Science Foundation of China 82102655Natural Science Foundation Breeding Project of Beijing Rehabilitation Hospital, Capital Medical University 2021-012
6 · The paper itself

Abstract

Nerve regeneration and repair still remain a huge challenge for both central nervous and peripheral nervous system. Although some therapeutic substances, including neuroprotective agents, clinical drugs and stem cells, as well as various growth factors, are found to be effective to promote nerve repair, a carrier system that possesses a sustainable release behavior, in order to ensure high on-site concentration during the whole repair and regeneration process, and high bioavailability is still highly desirable. Hydrogel, as an ideal delivery system, has an excellent loading capacity and sustainable release behavior, as well as tunable physical and chemical properties to adapt to various biomedical scenarios; thus, it is thought to be a suitable carrier system for nerve repair. This paper reviews the structure and classification of hydrogels and summarizes the fabrication and processing methods that can prepare a suitable hydrogel carrier with specific physical and chemical properties. Furthermore, the modulation of the physical and chemical properties of hydrogels is also discussed in detail in order to obtain a better therapeutic effect to promote nerve repair. Finally, the future perspectives of hydrogel microsphere carriers for stroke rehabilitation are highlighted.

Indexed as

carrierfabricationhydrogelnerve repairstroke

Identifiers

PMID35458307
PMCPMC9031091

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.