Evidence map›Paper›PMID 35458761›Full record

ArticleMolecules (Basel, Switzerland)2022

Discovery of Bispecific Lead Compounds from

Sanjay Kumar, Sherif A El-Kafrawy, Shiv Bharadwaj, S S Maitra, Thamir A Alandijany, Arwa A Faizo, Aiah M Khateb, Vivek Dhar Dwivedi, Esam I Azhar

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Advancement in the Development of Therapeutics Against Zika Virus Infection.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Sanjay KumarSchool of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Sherif A El-KafrawySpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.ORCID 0000-0002-3667-7529
Shiv BharadwajLaboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences v.v.i., BIOCEV Research Center, 252 50 Vestec, Czech Republic.ORCID 0000-0003-2832-8617
S S MaitraSchool of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Thamir A AlandijanySpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.ORCID 0000-0001-9130-4031
Arwa A FaizoSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.
Aiah M KhatebSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.
Vivek Dhar DwivediCenter for Bioinformatics, Computational and Systems Biology, Pathfinder Research and Training Foundation, Greater Noida 201308, India.ORCID 0000-0003-0767-1328
Esam I AzharSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.ORCID 0000-0002-1736-181X
King Abdulaziz University · SAJawaharlal Nehru University · INCzech Academy of Sciences, Institute of Biotechnology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV) has been characterized as one of many potential pathogens and placed under future epidemic outbreaks by the WHO. However, a lack of potential therapeutics can result in an uncontrolled pandemic as with other human pandemic viruses. Therefore, prioritized effective therapeutics development has been recommended against ZIKV. In this context, the present study adopted a strategy to explore the lead compounds from

Indexed as

AzadirachtaZika VirusZika Virus InfectionAntiviral AgentsFlavonoidsHumansLeadMolecular Docking SimulationPeptide HydrolasesProtease InhibitorsRNA-Dependent RNA PolymeraseViral Nonstructural ProteinsAntiviral AgentsFlavonoidsLeadPeptide HydrolasesProtease InhibitorsRNA-Dependent RNA PolymeraseViral Nonstructural ProteinsAzadirachta indicaflavonoidsmolecular dynamicsNS2B-NS3 proteaseNS5 RdRptherapeuticsZika virus

Identifiers

PMID35458761
PMCPMC9025849
OpenAlexW4224251654

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.