ArticleScientific reports2022
Protein-bound sialic acid in saliva contributes directly to salivary anti-influenza virus activity.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- A biomimetic cryoprotectant preserves extracellular vesicles bioactivity for intravenous administration and potentiates wound healing.Journal of nanobiotechnology · 2026Article
- Influence of Carbon Dioxide and pH on Influenza Virus in Sessile Saliva Droplets.Environmental science & technology · 2026Article
- Characteristics of Subgingival Plaque Microbiome in Japanese Older Adults With Healthy Gingiva.Journal of clinical periodontology · 2025Article
- Article
- Seasonal influenza viruses decay more rapidly at intermediate humidity in droplets containing saliva compared to respiratory mucus.Applied and environmental microbiology · 2024Article
- Salivary IgA and vimentin differentiate in vitro SARS-CoV-2 infection: A study of 290 convalescent COVID-19 patients.Mucosal immunology · 2024Article
- Advances in Research on Pig Salivary Analytes: A Window to Reveal Pig Health and Physiological Status.Animals : an open access journal from MDPI · 2024Review
- Mineralo-organic particles inhibit influenza A virus infection by targeting viral hemagglutinin activity.Nanomedicine (London, England) · 2024Article
- The need for integrated research autopsies in the era of precision oral medicine.Journal of the American Dental Association (1939) · 2023Review
- Comparison of proteins with anti-influenza virus effects in parotid and submandibular-sublingual saliva in humans.BMC oral health · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral cavity is an entrance for respiratory viruses, such as influenza. Recently, saliva has been shown to exert both antimicrobial and antiviral activities. Thus, saliva may be a biological factor that contributes to the prevention of influenza infection. However, the actual salivary anti-influenza A virus (IAV) activity in individuals and its determinant factors are unknown. By assessing individual variations in salivary anti-IAV activity in 92 people using an established new high-throughput system in this study, we found that the anti-IAV activity varied widely between individuals and showed a significant positive correlation with protein-bound sialic acid (BSA) level (ρ = 0.473; p < 0.001). Furthermore, the anti-IAV activity of saliva with enzymatically reduced BSA content was significantly lower. These results indicate that BSA is a direct regulator of salivary anti-IAV activity and is a determinant of individual differences. Additionally, after comparing the anti-IAV activity across the groups by age, anti-IAV activity in young people (aged 5-19 years) were lower than in adults aged 20-59 years and elderly people aged 60-79 years. Our study suggests that BSA levels in saliva may be important in preventing influenza infection.
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